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    GC gamma-glutamyl carboxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCprovided by FlyBase
    Official Full Name
    gamma-glutamyl carboxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035245
    Locus tag
    Dmel_CG13927
    See related
    AllianceGenome:FB:FBgn0035245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13927; dgammaC; DgammaC; dGC; Dmel\CG13927; gammaC
    Summary
    Enables gamma-glutamyl carboxylase activity. Predicted to be involved in vitamin K metabolic process. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    62A9-62A9; 3-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1623179..1629301, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1623179..1629301, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45814 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ATP binding cassette subfamily B member 7 Neighboring gene uncharacterized protein Neighboring gene neuronal Synaptobrevin Neighboring gene Methyltransferase like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila. Walker CS, et al. J Biol Chem, 2001 Mar 16. PMID 11110799
    2. Biochemical characterization of Drosophila gamma-glutamyl carboxylase and its role in fly development. Bandyopadhyay PK, et al. Insect Mol Biol, 2006 Apr. PMID 16640725
    3. Improvement of the recombinant human coagulation factor IX expression by co-expression of a novel transcript of Drosophila γ carboxylase in a human cell line. Moniri Javadhesari S, et al. Biotechnol Lett, 2020 Nov. PMID 32514789
    4. Expression of biologically active human clotting factor IX in Drosophila S2 cells: γ-carboxylation of a human vitamin K-dependent protein by the insect enzyme. Vatandoost J, et al. Biotechnol Prog, 2012 Jan-Feb. PMID 22012919
    5. Targeted mutagenesis by homologous recombination in D. melanogaster. Rong YS, et al. Genes Dev, 2002 Jun 15. PMID 12080094, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gamma-glutamyl carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-glutamyl carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-glutamyl carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-glutamic acid carboxylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin K metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamyl carboxylase
    Names
    CG13927-PA
    CG13927-PB
    GC-PA
    GC-PB
    gamma-glutamyl-carboxylase
    NP_001163323.1
    NP_523885.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1623179..1629301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079161.4 → NP_523885.2  gamma-glutamyl carboxylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523885.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A089X5C5, Q9W0C4
      Related
      FBpp0072701
      Conserved Domains (3) summary
      smart00752
      Location:73 → 330
      HTTM; Horizontally Transferred TransMembrane Domain
      pfam05090
      Location:83 → 505
      VKG_Carbox; Vitamin K-dependent gamma-carboxylase
      cl21464
      Location:557 → 608
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_001169852.1 → NP_001163323.1  gamma-glutamyl carboxylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A089X5C5, Q9W0C4
      Conserved Domains (3) summary
      smart00752
      Location:73 → 330
      HTTM; Horizontally Transferred TransMembrane Domain
      pfam05090
      Location:83 → 505
      VKG_Carbox; Vitamin K-dependent gamma-carboxylase
      cl21464
      Location:557 → 608
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NDA0 Q9NDA0
    Q9W0C4 Q9W0C4

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