alpha-PheRS Phenylalanyl-tRNA synthetase, alpha-subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: alpha-PheRSprovided by FlyBase
Official Full Name: Phenylalanyl-tRNA synthetase, alpha-subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0030007
Locus tag: Dmel_CG2263
See related: AllianceGenome:FB:FBgn0030007
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2263; Dmel\CG2263
Summary: Enables phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8143904..8145602, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8037937..8039635, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Knockout of alpha-PheRS (CG2263) and beta-PheRS (CG5706) causes protein mistranslation and affects cellular physiology and development.
Title: Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables phenylalanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylalanine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables phenylalanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables phenylalanine-tRNA ligase activity	TAS Traceable Author Statement more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylalanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in phenylalanyl-tRNA aminoacylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phenylalanyl-tRNA aminoacylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info

Names: CG2263-PA; Phenylalanyl-tRNA synthetase alpha subunit; alpha-PheRS-PA

NP_572448.1

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