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    ste24a prenyl protease type I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ste24aprovided by FlyBase
    Official Full Name
    prenyl protease type Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034176
    Locus tag
    Dmel_CG9000
    See related
    AllianceGenome:FB:FBgn0034176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9000; Dmel\CG9000; Dmel\Ste24; Dmel\Ste24a; Ste24a
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; indirect flight muscle cell; and organism. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ste24a in Genome Data Viewer
    Location:
    53E4-53E4; 2-81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17000244..17001941, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12887749..12889446, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Calbindin 53E Neighboring gene uncharacterized protein Neighboring gene ste24c prenyl protease type I Neighboring gene ste24b prenyl protease type I Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene Nuclear inhibitor of Protein phosphatase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency. Agarwal AK, et al. J Investig Med, 2006 May. PMID 17152860
    2. Type-I prenyl protease function is required in the male germline of Drosophila melanogaster. Adolphsen K, et al. G3 (Bethesda), 2012 Jun. PMID 22690372, Free PMC Article
    3. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
    4. An ABC transporter controls export of a Drosophila germ cell attractant. Ricardo S, et al. Science, 2009 Feb 13. PMID 19213920, Free PMC Article
    5. Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T in Drosophila melanogaster Indirect Flight Muscles. Katti P, et al. G3 (Bethesda), 2017 Oct 5. PMID 28866639, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prenyl protease type I
    Names
    CG9000-PA
    ste24a-PA
    NP_611175.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17000244..17001941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137331.3 → NP_611175.1  prenyl protease type I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611175.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K172
      Related
      FBpp0086207
      Conserved Domains (3) summary
      COG0501
      Location:153 → 440
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:219 → 439
      Peptidase_M48; Peptidase family M48
      pfam16491
      Location:31 → 216
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K172 Q7K172

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