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    Adck1 aarF domain containing kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adck1provided by FlyBase
    Official Full Name
    aarF domain containing kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035039
    Locus tag
    Dmel_CG3608
    See related
    AllianceGenome:FB:FBgn0035039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Adck; ADCK1; cg3608; CG3608; dADCK1; Dmel\CG3608
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Involved in negative regulation of mitochondrial fusion and positive regulation of cristae formation. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including adult fat body; adult head; and gut section. Orthologous to human ADCK1 (aarF domain containing kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adck1 in Genome Data Viewer
    Location:
    60D9-60D9; 2-107 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24611703..24613906)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20499226..20501429)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine sensor upstream of TORC1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43787 Neighboring gene Cytochrome P450 9c1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster. Wisidagama DR, et al. Dev Dyn, 2019 Sep. PMID 31175694, Free PMC Article
    2. Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. Yoon W, et al. PLoS Genet, 2019 May. PMID 31125351, Free PMC Article
    3. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article
    4. p53- and ERK7-dependent ribosome surveillance response regulates Drosophila insulin-like peptide secretion. Hasygar K, et al. PLoS Genet, 2014 Nov. PMID 25393288, Free PMC Article
    5. ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD. Park J, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34551427, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aarF domain containing kinase 1
    Names
    Adck1-PA
    Adck1-PB
    CG3608-PA
    CG3608-PB
    aarF domain containing kinase
    aarf domain-containing kinase 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24611703..24613906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138103.3 → NP_611947.2  aarF domain containing kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611947.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W133
      Related
      FBpp0072227
      Conserved Domains (1) summary
      cd13969
      Location:118 → 369
      ADCK1-like; aarF domain containing kinase 1 and similar proteins

    2. NM_001299922.1 → NP_001286851.1  aarF domain containing kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W133
      Conserved Domains (1) summary
      cd13969
      Location:118 → 369
      ADCK1-like; aarF domain containing kinase 1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W133.2 Q9W133

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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