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    Eps-15 Epidermal growth factor receptor pathway substrate clone 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37961, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eps-15provided by FlyBase
    Official Full Name
    Epidermal growth factor receptor pathway substrate clone 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0035060
    Locus tag
    Dmel_CG16932
    See related
    AllianceGenome:FB:FBgn0035060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aa2/2; anon-WO0118547.85; CG16932; Dmel\CG16932; EH1; eps-15; EPS-15; eps15; Eps15; EPS15; i31
    Summary
    Predicted to enable calcium ion binding activity. Involved in negative regulation of Notch signaling pathway; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle endocytosis. Located in cytoplasm. Is active in neuromuscular junction. Is extrinsic component of presynaptic endocytic zone membrane. Colocalizes with synaptic vesicle. Is expressed in adult head; lamina; larval central nervous system; outer photoreceptor cell; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Eps-15 in Genome Data Viewer
    Location:
    60E1-60E1; 2-107 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24768314..24775265, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20655837..20662788, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase E12 Neighboring gene antisense RNA:CR44067 Neighboring gene eggless Neighboring gene Larval cuticle protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Eps15 as antigen recognized by the monoclonal antibodies aa2 and ab52 of the Wuerzburg Hybridoma Library against Drosophila brain. Halder P, et al. PLoS One, 2011. PMID 22206011, Free PMC Article
    2. Oncogenic breakdowns in endocytic adaptor proteins. Crosetto N, et al. FEBS Lett, 2005 Jun 13. PMID 15943966
    3. An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction. Winther ÅM, et al. J Neurosci, 2015 Nov 4. PMID 26538647, Free PMC Article
    4. Synaptic Vesicle Endocytosis in Different Model Systems. Gan Q, et al. Front Cell Neurosci, 2018. PMID 30002619, Free PMC Article
    5. A positive feedback loop between Flower and PI(4,5)P(2) at periactive zones controls bulk endocytosis in Drosophila. Li TN, et al. Elife, 2020 Dec 10. PMID 33300871, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of presynaptic endocytic zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epidermal growth factor receptor pathway substrate clone 15
    Names
    CG16932-PA
    CG16932-PB
    CG16932-PC
    CG16932-PD
    Eps-15-PA
    Eps-15-PB
    Eps-15-PC
    Eps-15-PD
    Eps15 homologue 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24768314..24775265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166686.1 → NP_726481.1  epidermal growth factor receptor pathway substrate clone 15, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MMD3, Q8WQ61
      Related
      FBpp0072338, FBtr0072433
      Conserved Domains (4) summary
      smart00027
      Location:307 → 402
      EH; Eps15 homology domain
      cd00052
      Location:137 → 202
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:436 → 556
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl12013
      Location:401 → 579
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_166687.1 → NP_726482.1  epidermal growth factor receptor pathway substrate clone 15, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MMD2, Q8WQ61
      Related
      FBpp0072339, FBtr0072434
      Conserved Domains (4) summary
      smart00027
      Location:307 → 402
      EH; Eps15 homology domain
      cd00052
      Location:137 → 202
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:436 → 556
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl12013
      Location:401 → 579
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_138121.2 → NP_611965.2  epidermal growth factor receptor pathway substrate clone 15, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611965.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ61, Q9W111
      Related
      FBpp0072340, FBtr0072435
      Conserved Domains (4) summary
      smart00027
      Location:307 → 402
      EH; Eps15 homology domain
      cd00052
      Location:137 → 202
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam08286
      Location:529 → 584
      Spc24; Spc24 subunit of Ndc80
      cl23720
      Location:445 → 548
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. NM_001259573.1 → NP_001246502.1  epidermal growth factor receptor pathway substrate clone 15, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTP7
      Conserved Domains (4) summary
      smart00027
      Location:307 → 402
      EH; Eps15 homology domain
      cd00052
      Location:137 → 202
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:436 → 556
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl12013
      Location:401 → 579
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E3CTP7 E3CTP7
    Q8MMD2 Q8MMD2
    Q8MMD3 Q8MMD3
    Q8WQ61 Q8WQ61
    Q9W111 Q9W111

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