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    MRP Multidrug-Resistance like Protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRPprovided by FlyBase
    Official Full Name
    Multidrug-Resistance like Protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032456
    Locus tag
    Dmel_CG6214
    See related
    AllianceGenome:FB:FBgn0032456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ABCC1; CG6214; DmCG6214; Dmel\CG6214; dmrp; dMRP; dMRP/CG6214; dMRP1; lincRNA.123; Mrp; Mrp1; MRP1
    Summary
    Enables ATPase-coupled inorganic anion transmembrane transporter activity. Involved in monoatomic anion transmembrane transport; renal tubular secretion; and response to toxic substance. Located in plasma membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MRP in Genome Data Viewer
    Location:
    33F3-33F5; 2-47 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12719045..12766546)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12719045..12744807)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PIH1 domain containing 1 Neighboring gene mir-9382 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46206 Neighboring gene long noncoding RNA: testis-specific 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercury. Prince L, et al. Toxicol Sci, 2014 Aug 1. PMID 24863968, Free PMC Article
    2. Convergent intron loss of MRP1 in Drosophila and mosquito species. Zhan LL, et al. J Hered, 2012 Jan-Feb. PMID 21908794
    3. The high turnover Drosophila multidrug resistance-associated protein shares the biochemical features of its human orthologues. Szeri F, et al. Biochim Biophys Acta, 2009 Feb. PMID 19059376
    4. In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein. Karasik A, et al. PLoS One, 2018. PMID 30312334, Free PMC Article
    5. Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-β-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter. Karasik A, et al. FASEB J, 2018 Feb. PMID 28939593, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the second E2G binding-similar to human ABCC2-allosterically stimulates transport activity of DMRP.
      Title: Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-β-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter.
    2. dMRP and MET are not the dominant methotrexate (MTX) transporters in the tubules when flies are reared on MTX-enriched diets.
      Title: Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster.
    3. DMRP is capable of transporting a known MRP1 substrate and is a high capacity ATP-dependent, vanadate-sensitive organic anion transporter.
      Title: The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 12731125-12735818 mobile_element_type = transposon:F{}349
    • Loc: 12763895-12764039 mobile_element_type = transposon:BS{}351

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled inorganic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic anion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in renal tubular secretion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Multidrug-Resistance like protein 1
    Names
    CG6214-PA
    CG6214-PB
    CG6214-PC
    CG6214-PD
    CG6214-PE
    CG6214-PF
    CG6214-PG
    CG6214-PH
    CG6214-PI
    CG6214-PJ
    CG6214-PK
    CG6214-PL
    CG6214-PM
    CG6214-PN
    CG6214-PO
    CG6214-PP
    CG6214-PQ
    CG6214-PR
    MRP-PA
    MRP-PB
    MRP-PC
    MRP-PD
    MRP-PE
    MRP-PF
    MRP-PG
    MRP-PH
    MRP-PI
    MRP-PJ
    MRP-PK
    MRP-PL
    MRP-PM
    MRP-PN
    MRP-PO
    MRP-PP
    MRP-PQ
    MRP-PR
    Multidrug-resistance protein
    multidrug resistance like protein
    multidrug resistance-associated protein
    multidrug resistance-like protein
    multidrug resistance-like protein 1
    NP_001303319.1
    NP_609591.2
    NP_723772.2
    NP_995690.1
    NP_995691.1
    NP_995692.1
    NP_995693.1
    NP_995694.1
    NP_995695.1
    NP_995696.1
    NP_995697.1
    NP_995698.1
    NP_995699.1
    NP_995700.1
    NP_995701.1
    NP_995702.1
    NP_995703.1
    NP_995704.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12719045..12766546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316390.1 → NP_001303319.1  Multidrug-Resistance like protein 1, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WIA2, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1485
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1491
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    2. NM_205977.2 → NP_995699.1  Multidrug-Resistance like protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC7, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 601
      ABC_membrane; ABC transporter transmembrane region

    3. NM_205980.2 → NP_995702.1  Multidrug-Resistance like protein 1, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995702.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9C5, Q9VK56
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1548
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1308 → 1528
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 601
      ABC_membrane; ABC transporter transmembrane region

    4. NM_205973.2 → NP_995695.1  Multidrug-Resistance like protein 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC6, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 601
      ABC_membrane; ABC transporter transmembrane region

    5. NM_205979.2 → NP_995701.1  Multidrug-Resistance like protein 1, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995701.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC5, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 601
      ABC_membrane; ABC transporter transmembrane region

    6. NM_205970.2 → NP_995692.1  Multidrug-Resistance like protein 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995692.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC3, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    7. NM_205981.2 → NP_995703.1  Multidrug-Resistance like protein 1, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC2, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:988 → 1259
      ABC_membrane; ABC transporter transmembrane region

    8. NM_205969.2 → NP_995691.1  Multidrug-Resistance like protein 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC1, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    9. NM_205982.2 → NP_995704.1  Multidrug-Resistance like protein 1, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTB7, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    10. NM_165020.3 → NP_723772.2  Multidrug-Resistance like protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723772.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9C5, Q9VK56
      Related
      FBpp0089056
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1548
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1308 → 1528
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 601
      ABC_membrane; ABC transporter transmembrane region

    11. NM_205976.2 → NP_995698.1  Multidrug-Resistance like protein 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTD0, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    12. NM_205975.2 → NP_995697.1  Multidrug-Resistance like protein 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC9, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:988 → 1259
      ABC_membrane; ABC transporter transmembrane region

    13. NM_205974.2 → NP_995696.1  Multidrug-Resistance like protein 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC8, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    14. NM_205972.2 → NP_995694.1  Multidrug-Resistance like protein 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC4, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:988 → 1259
      ABC_membrane; ABC transporter transmembrane region

    15. NM_205971.2 → NP_995693.1  Multidrug-Resistance like protein 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTC0, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1548
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1308 → 1528
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    16. NM_205968.2 → NP_995690.1  Multidrug-Resistance like protein 1, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTB9, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    17. NM_205978.2 → NP_995700.1  Multidrug-Resistance like protein 1, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTB8, Q8T9C5
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region

    18. NM_135747.4 → NP_609591.2  Multidrug-Resistance like protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609591.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9C5, Q9I7N0
      Related
      FBpp0089057
      Conserved Domains (4) summary
      TIGR00957
      Location:14 → 1547
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:1307 → 1527
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:649 → 848
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:338 → 605
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WIA2 A0A0S0WIA2
    Q7KTB7 Q7KTB7
    Q7KTB8 Q7KTB8
    Q7KTB9 Q7KTB9
    Q7KTC0 Q7KTC0
    Q7KTC1 Q7KTC1
    Q7KTC2 Q7KTC2
    Q7KTC3 Q7KTC3
    Q7KTC4 Q7KTC4
    Q7KTC5 Q7KTC5
    Q7KTC6 Q7KTC6
    Q7KTC7 Q7KTC7
    Q7KTC8 Q7KTC8
    Q7KTC9 Q7KTC9
    Q7KTD0 Q7KTD0
    Q8T9C5 Q8T9C5
    Q9I7N0 Q9I7N0
    Q9VK56 Q9VK56

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