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    vig2 vig2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vig2provided by FlyBase
    Official Full Name
    vig2provided by FlyBase
    Primary source
    FLYBASE:FBgn0046214
    Locus tag
    Dmel_CG11844
    See related
    AllianceGenome:FB:FBgn0046214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.290; BcDNA:SD06613; CG11844; Dmel\CG11844; Hero45; vig-2; Vig2
    Summary
    Predicted to enable RNA binding activity. Involved in heterochromatin organization. Located in cytoplasm; nucleus; and polytene chromosome. Is expressed in adult head. Orthologous to several human genes including SERBP1 (SERPINE1 mRNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vig2 in Genome Data Viewer
    Location:
    96C1-96C1; 3-87 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25123373..25125619)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20949095..20951341)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Neprilysin-like 16 Neighboring gene Tubulin tyrosine ligase-like 5 Neighboring gene uncharacterized protein Neighboring gene Molybdenum cofactor synthesis 2B Neighboring gene Molybdenum cofactor synthesis 2A Neighboring gene Caliban

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electron transfer dissociation in conjunction with collision activation to investigate the Drosophila melanogaster phosphoproteome. Domon B, et al. J Proteome Res, 2009 Jun. PMID 19435317
    2. A Simple Cross-Linking/Mass Spectrometry Workflow for Studying System-wide Protein Interactions. Götze M, et al. Anal Chem, 2019 Aug 6. PMID 31283178
    3. Birth of a new gene on the Y chromosome of Drosophila melanogaster. Carvalho AB, et al. Proc Natl Acad Sci U S A, 2015 Oct 6. PMID 26385968, Free PMC Article
    4. Drosophila RISC component VIG and its homolog Vig2 impact heterochromatin formation. Gracheva E, et al. PLoS One, 2009 Jul 8. PMID 19584931, Free PMC Article
    5. piRNA silencing contributes to interspecies hybrid sterility and reproductive isolation in Drosophila melanogaster. Kotov AA, et al. Nucleic Acids Res, 2019 May 7. PMID 30788506, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vig2 binds and regulates core histone H2A and H3 mRNA via interaction with their 3' UTRs.
      Title: dCas9-targeted locus-specific protein isolation method identifies histone gene regulators.
    2. Data indicate an unidentified gene (flagrante delicto Y, FDY) that originated from a recent duplication of the autosomal gene vig2 to the Y chromosome.
      Title: Birth of a new gene on the Y chromosome of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vig2
    Names
    CG11844-PA
    CG11844-PB
    CG11844-PC
    CG11844-PD
    vig2-PA
    vig2-PB
    vig2-PC
    vig2-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25123373..25125619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170204.2 → NP_733083.1  vig2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RIY3, Q9VBX3
      Related
      FBpp0084150
      Conserved Domains (1) summary
      pfam04774
      Location:175 → 273
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

    2. NM_170206.3 → NP_733085.1  vig2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733085.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0H4CMP0, Q960D3
      Related
      FBpp0084151
      Conserved Domains (1) summary
      pfam04774
      Location:144 → 242
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

    3. NM_001104443.2 → NP_001097913.1  vig2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0H4CMP0, Q960D3
      Conserved Domains (1) summary
      pfam04774
      Location:144 → 242
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

    4. NM_170205.3 → NP_733084.1  vig2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0H4CMP0, Q960D3
      Related
      FBpp0084152
      Conserved Domains (1) summary
      pfam04774
      Location:144 → 242
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960D3 Q960D3
    Q9VBX3 Q9VBX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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