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    LKRSDH Lysine ketoglutarate reductase/saccharopine dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34064, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LKRSDHprovided by FlyBase
    Official Full Name
    Lysine ketoglutarate reductase/saccharopine dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286198
    Locus tag
    Dmel_CG7144
    See related
    AllianceGenome:FB:FBgn0286198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0149856.1; BEST:CK02318; CG7144; CK02318; dLKR; Dmel\CG7144; LKR; lys; SDH
    Summary
    Enables several functions, including nuclear receptor binding activity; saccharopine dehydrogenase (NAD+, L-lysine-forming) activity; and transcription corepressor activity. Involved in lysine catabolic process; negative regulation of ecdysone receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in adult head; adult heart; and salivary gland. Human ortholog(s) of this gene implicated in hyperlysinemia. Orthologous to human AASS (aminoadipate-semialdehyde synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LKRSDH in Genome Data Viewer
    Location:
    28C4-28C4; 2-28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7791175..7795959, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7791175..7795959, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bromodomain containing 7/9 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44825 Neighboring gene Homocysteine-induced endoplasmic reticulum protein Neighboring gene r2d2 Neighboring gene Cell division cycle 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetics and biochemistry of red fat cells in Drosophila melanogaster. GRELL EH. Genetics, 1961 Aug. PMID 13708467, Free PMC Article
    2. Metabolomic Analysis Reveals That the Drosophila melanogaster Gene lysine Influences Diverse Aspects of Metabolism. St Clair SL, et al. Genetics, 2017 Dec. PMID 28986444, Free PMC Article
    3. LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes. Lv P, et al. Nat Commun, 2024 Apr 18. PMID 38637528, Free PMC Article
    4. dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. Cakouros D, et al. J Cell Biol, 2008 Aug 11. PMID 18695041, Free PMC Article
    5. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. Emtenani S, et al. EMBO J, 2022 Jun 14. PMID 35319107, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our efforts revealed that lys encodes the Drosophila homolog of Lysine Ketoglutarate Reductase/Saccharopine Dehydrogenase, which is required for the enzymatic degradation of lysine. Furthermore, this approach also allowed us to simultaneously survey a large swathe of intermediate metabolism, thus demonstrating that Drosophila lysine catabolism is complex and capable of influencing seemingly unrelated metabolic pathways
      Title: Metabolomic Analysis Reveals That the Drosophila melanogaster Gene lysine Influences Diverse Aspects of Metabolism.
    2. A novel cofactor, Drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH), is involved in ecdysone-mediated transcription.
      Title: dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables saccharopine dehydrogenase (NAD+, L-lysine-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables saccharopine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lysine biosynthetic process via aminoadipic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ecdysone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine ketoglutarate reductase/saccharopine dehydrogenase
    Names
    CG7144-PA
    CG7144-PB
    LKRSDH-PA
    LKRSDH-PB
    drosophila lysine ketoglutarate reductase
    drosophila lysine ketoglutarate reductase (dLKR)/saccharopine dehydrogenase (SDH)
    lysine
    lysine ketoglutarate Reductase/Saccharopine dehydrogenase
    lysine ketoglutarate reductase
    saccharopine dehydogenase
    NP_001285719.1
    NP_609150.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7791175..7795959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298790.1 → NP_001285719.1  lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP53, Q9VLX0
      Conserved Domains (4) summary
      PLN02819
      Location:23 → 922
      PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
      cd12189
      Location:23 → 465
      LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
      pfam03435
      Location:486 → 602
      Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
      pfam16653
      Location:606 → 917
      Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain

    2. NM_135306.3 → NP_609150.2  lysine ketoglutarate reductase/saccharopine dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609150.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP53, Q9VLX0
      Related
      FBpp0079118
      Conserved Domains (4) summary
      PLN02819
      Location:23 → 922
      PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
      cd12189
      Location:23 → 465
      LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
      pfam03435
      Location:486 → 602
      Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
      pfam16653
      Location:606 → 917
      Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLX0 Q9VLX0

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