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    mag magro [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40267, updated on 17-Dec-2024

    Summary

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    Official Symbol
    magprovided by FlyBase
    Official Full Name
    magroprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036996
    Locus tag
    Dmel_CG5932
    See related
    AllianceGenome:FB:FBgn0036996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5932; Dmel\CG5932; lipA; Mag; Magro
    Summary
    Enables sterol ester esterase activity and triacylglycerol lipase activity. Involved in cholesterol homeostasis and triglyceride homeostasis. Located in cytoplasmic vesicle. Is expressed in embryonic/larval alimentary canal and embryonic/larval proventriculus. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mag in Genome Data Viewer
    Location:
    77C4-77C4; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20460683..20462274)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20453783..20455374)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 8 Neighboring gene artichoke Neighboring gene uncharacterized protein Neighboring gene L-threonine dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila HNF4 acts in distinct tissues to direct a switch between lipid storage and export in the gut. Vonolfen MC, et al. Cell Rep, 2024 Sep 24. PMID 39235946
    2. Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila. Subramanian M, et al. BMC Neurosci, 2013 Dec 18. PMID 24350669, Free PMC Article
    3. Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro. Sieber MH, et al. Cell Metab, 2012 Jan 4. PMID 22197324, Free PMC Article
    4. Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila. Kohyama-Koganeya A, et al. PLoS One, 2017. PMID 28045997, Free PMC Article
    5. RNA-seq analysis of diet-driven obesity and anti-obesity effects of quercetin glucoside or epigallocatechin gallate in Drosophila adults. Azuma M, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30720195

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol ester esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triacylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    magro
    Names
    CG5932-PA
    mag-PA
    NP_649229.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20460683..20462274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140972.3 → NP_649229.1  magro [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649229.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPE9
      Related
      FBpp0077854
      Conserved Domains (3) summary
      COG0596
      Location:56 → 366
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam04083
      Location:34 → 94
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:76 → 197
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPE9 Q9VPE9

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