Sec16b SEC16 homolog B, endoplasmic reticulum export factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec16bprovided by MGI
Official Full Name: SEC16 homolog B, endoplasmic reticulum export factorprovided by MGI
Primary source: MGI:MGI:2148802
See related: Ensembl:ENSMUSG00000026589 AllianceGenome:MGI:2148802
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rgpr; Lztr2; Rgpr-p117
Summary: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and protein localization to endoplasmic reticulum exit site. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in ER to Golgi transport vesicle membrane and endoplasmic reticulum exit site. Is expressed in dorsal root ganglion; forelimb digit mesenchyme; hindlimb; jaw; and musculoskeletal system. Orthologous to several human genes including SEC16B (SEC16 homolog B, endoplasmic reticulum export factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 13.8), duodenum adult (RPKM 10.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H1; 1 68.0 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (157334303..157395995)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (157506733..157568425)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal SEC16B modulates obesity by regulating chylomicron metabolism.
Title: Intestinal SEC16B modulates obesity by regulating chylomicron metabolism.
Transcriptional regulation of the ER stress-inducible gene Sec16B in Neuro2a cells.
Title: Transcriptional regulation of the ER stress-inducible gene Sec16B in Neuro2a cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum organization	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome fission	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein exit from endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in protein localization to endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ER to Golgi transport vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein transport protein Sec16B

Names: SEC16 homolog B; leucine zipper transcription regulator 2; protein SEC16 homolog B; regucalcin gene promoter region-related protein p117; regucalcin gene promotor region related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159986.1 → NP_001153458.1 protein transport protein Sec16B

See identical proteins and their annotated locations for NP_001153458.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AB063356, AK173302, CO043178

Consensus CDS

CCDS15400.1

UniProtKB/Swiss-Prot

E9QL61, Q69Z64, Q6PCR8, Q91XT4

Related

ENSMUSP00000107329.2, ENSMUST00000111700.8

Conserved Domains (2) summary

cd09233
Location:319 → 675

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

PHA03307
Location:674 → 1027

PHA03307; transcriptional regulator ICP4; Provisional
NM_033354.3 → NP_203505.3 protein transport protein Sec16B

See identical proteins and their annotated locations for NP_203505.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK173302, BY151383, CO043178

Consensus CDS

CCDS15400.1

UniProtKB/Swiss-Prot

E9QL61, Q69Z64, Q6PCR8, Q91XT4

Related

ENSMUSP00000083300.3, ENSMUST00000086130.9

Conserved Domains (2) summary

cd09233
Location:319 → 675

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

PHA03307
Location:674 → 1027

PHA03307; transcriptional regulator ICP4; Provisional

RNA

NR_027641.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate 5' UTR exon compared to variant 1. This creates a nonoverlapping upstream ORF (uORF) with a very strong Kozak signal that could encode a protein of 46 aa. Although the Kozak signal of the original ORF also has a strong Kozak signal, the signal for the uORF is stronger and is likely to prevent translation from the original ORF. Therefore, this transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is not likely to encode a protein.

Source sequence(s)

AK173302, BY151383, CO043178

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

157334303..157395995

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154459.1 → XP_036010352.1 protein transport protein Sec16B isoform X1

UniProtKB/Swiss-Prot

E9QL61, Q69Z64, Q6PCR8, Q91XT4

Conserved Domains (2) summary

cd09233
Location:319 → 675

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

PHA03307
Location:674 → 1027

PHA03307; transcriptional regulator ICP4; Provisional
XM_006497049.2 → XP_006497112.1 protein transport protein Sec16B isoform X2

Conserved Domains (2) summary

cd09233
Location:225 → 581

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

PHA03307
Location:580 → 933

PHA03307; transcriptional regulator ICP4; Provisional
XM_036154460.1 → XP_036010353.1 protein transport protein Sec16B isoform X3

Conserved Domains (1) summary

cd09233
Location:319 → 546

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
XM_036154461.1 → XP_036010354.1 protein transport protein Sec16B isoform X3

Conserved Domains (1) summary

cd09233
Location:319 → 546

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
XM_017312983.2 → XP_017168472.1 protein transport protein Sec16B isoform X1

UniProtKB/Swiss-Prot

E9QL61, Q69Z64, Q6PCR8, Q91XT4

Conserved Domains (2) summary

cd09233
Location:319 → 675

ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

PHA03307
Location:674 → 1027

PHA03307; transcriptional regulator ICP4; Provisional