Tymp thymidine phosphorylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tympprovided by MGI
Official Full Name: thymidine phosphorylaseprovided by MGI
Primary source: MGI:MGI:1920212
See related: Ensembl:ENSMUSG00000022615 AllianceGenome:MGI:1920212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TP; Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik
Summary: Enables thymidine phosphorylase activity. Involved in dTMP catabolic process. Predicted to be active in cytosol. Is expressed in alimentary system; axial skeleton; central nervous system; hindlimb; and retina. Used to study mitochondrial DNA depletion syndrome 1. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 180.1), liver adult (RPKM 127.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.86 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89255834..89261282, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89371631..89377036, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma.
Title: Thymidine phosphorylase promotes angiogenesis and tumour growth in intrahepatic cholangiocarcinoma.
data identify TYMP as an astrocyte-derived permeability factor, and suggest TYMP and VEGFA together promote blood-brain barrier breakdown.
Title: Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions.
TYMP participates in multiple platelet signaling pathways and regulates platelet activation and thrombosis. Targeting TYMP might be a novel antiplatelet and antithrombosis therapy.
Title: Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.
Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
Title: Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice.
The PyNpase levels in mouse bladder tissue were significantly higher in BBN-treatment bladder cancer groups than in those in the control group
Title: Tissue levels of pyrimidine nucleoside phosphorylase activity in human and rodent bladder cancer and normal bladder tissue.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

D15Ertd785e (e-PCR), detects polymorphism
- UniSTS:167180

PMC139774P1 (e-PCR)
- UniSTS:270892

Tymp (e-PCR), detects polymorphism
- UniSTS:547168

RH136025 (e-PCR)
- UniSTS:210021

AW743235 (e-PCR)
- UniSTS:209131

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables thymidine phosphorylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thymidine phosphorylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in dTMP catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial genome maintenance	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial genome maintenance	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleoside metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleoside metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastric motility	IEA Inferred from Electronic Annotation more info
involved_in regulation of gastric motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
involved_in regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thymidine phosphorylase

Names: endothelial cell growth factor 1 (platelet-derived); gliostatin; platelet derived growth factor, endothelial cell; tdRPase

NP_612175.1

EC 2.4.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138302.3 → NP_612175.1 thymidine phosphorylase

See identical proteins and their annotated locations for NP_612175.1

Status: VALIDATED

Source sequence(s)

AC113976

Consensus CDS

CCDS27747.1

UniProtKB/Swiss-Prot

Q99N42

Related

ENSMUSP00000023285.5, ENSMUST00000023285.5

Conserved Domains (4) summary

PRK05820
Location:23 → 456

deoA; thymidine phosphorylase; Reviewed

smart00941
Location:374 → 448

PYNP_C; Pyrimidine nucleoside phosphorylase C-terminal domain

pfam00591
Location:96 → 326

Glycos_transf_3; Glycosyl transferase family, a/b domain

pfam02885
Location:24 → 84

Glycos_trans_3N; Glycosyl transferase family, helical bundle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

89255834..89261282 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028405.1: Suppressed sequence

Description

NM_028405.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.