Kctd2 potassium channel tetramerisation domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd2provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 2provided by MGI
Primary source: MGI:MGI:1917632
See related: Ensembl:ENSMUSG00000016940 AllianceGenome:MGI:1917632
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310012I15Rik
Summary: Predicted to enable cullin family protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KCTD2 (potassium channel tetramerization domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 23.4), cerebellum adult (RPKM 19.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.84 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115310915..115322100)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115420094..115431274)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of KCTD2 using a KCTD2-specific short-hairpin RNA in primary Ink4a/Arf-deficient murine astrocytes markedly increased self-renewal activity in addition with an increased expression of stem cell markers, and mouse in vivo intracranial tumor growth.
Title: KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183285.4 → NP_899108.3 BTB/POZ domain-containing protein KCTD2

See identical proteins and their annotated locations for NP_899108.3

Status: VALIDATED

Source sequence(s)

AL627096, AL645470

Consensus CDS

CCDS25634.1

UniProtKB/TrEMBL

F6SH71, Q4VBE7

Related

ENSMUSP00000099324.4, ENSMUST00000103035.10

Conserved Domains (2) summary

smart00225
Location:73 → 175

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:74 → 163

BTB_2; BTB/POZ domain

RNA

NR_175855.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627096, AL645470
NR_175856.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627096, AL645470
NR_175857.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627096, AL645470

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115310915..115322100

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249244.4 → XP_011247546.1 BTB/POZ domain-containing protein KCTD2 isoform X1

See identical proteins and their annotated locations for XP_011247546.1

UniProtKB/TrEMBL

F6SH71

Conserved Domains (1) summary

cd18389
Location:72 → 177

BTB_POZ_KCTD2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2)