Krt23 keratin 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt23provided by MGI
Official Full Name: keratin 23provided by MGI
Primary source: MGI:MGI:2148866
See related: Ensembl:ENSMUSG00000006777 AllianceGenome:MGI:2148866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K23; CK23; Haik1; Krt1-23
Summary: Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in lung; metanephros; nose; and submandibular gland primordium. Orthologous to human KRT23 (keratin 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 66.7), lung adult (RPKM 10.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.92 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (99368799..99383946, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (99477973..99493120, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPARA and MYC bind to sites within the Krt23 promoter
Title: Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

D11Mit330 (e-PCR), detects polymorphism
- UniSTS:126545

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 23

Names: cytokeratin-23; keratin complex 1, acidic, gene 23; type I intermediate filament cytokeratin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033373.2 → NP_203537.1 keratin, type I cytoskeletal 23

Status: VALIDATED

Source sequence(s)

AF102849, AK036901

Consensus CDS

CCDS25382.1

UniProtKB/Swiss-Prot

Q99PS0

UniProtKB/TrEMBL

Q3ULX3, Q544I8, Q8CB30

Related

ENSMUSP00000006969.8, ENSMUST00000006969.8

Conserved Domains (2) summary

pfam00038
Location:71 → 377

Filament; Intermediate filament protein

cl00788
Location:168 → 260

MttA_Hcf106; mttA/Hcf106 family