Pacrg PARK2 co-regulated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pacrgprovided by MGI
Official Full Name: PARK2 co-regulatedprovided by MGI
Primary source: MGI:MGI:1916560
See related: Ensembl:ENSMUSG00000037196 AllianceGenome:MGI:1916560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700008H23Rik
Summary: Enables ubiquitin protein ligase binding activity. Involved in flagellated sperm motility. Acts upstream of or within protein localization and spermatid development. Located in several cellular components, including cell body; manchette; and sperm midpiece. Is active in axonemal B tubule inner sheath and sperm flagellum. Is expressed in several structures, including brain; neural ectoderm; otocyst; pancreas trunk epithelium; and spinal cord ventricular layer. Orthologous to human PACRG (parkin coregulated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 92.0) and frontal lobe adult (RPKM 3.8) See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 7.8 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (10621938..11059078, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (10403009..10840191, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that aged single knockout Pacrg mouse and double knockout parkin-Pacrg mouse do not show behavioral or neuropathological deficits of the dopaminergic system. Collectively, these studies suggest that gene mediated deficiency in the mouse may alter pathways common to human pathogenesis but for as yet unknown reasons do not cause a pronounced Parkinson disease-like phenotype.
Title: Generation and characterisation of a parkin-Pacrg knockout mouse line and a Pacrg knockout mouse line.
Studies demonstrate that MEIG1/PACRG forms a complex in the manchette and that this complex is necessary to transport cargos, such as SPAG16L, to build the sperm flagella.
Title: A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella.
Pacrg is required for motile cilia function and may be involved in the pathogenesis of hydrocephalus.
Title: Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse.
Findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis.
Title: MEIG1 is essential for spermiogenesis in mice.
The results of this study indicated that expression of Pacrg in the cells associated with the cerebral ventricle, in addition to the aqueduct of Sylvius and choroid plexus. And strong expression was observed since newborn period to adulthood.
Title: Expression and localization of the Parkin co-regulated gene in mouse CNS suggests a role in ependymal cilia function.
These results suggest that the transcriptional co-regulation of Pacrg and parkin leads to a similar regional protein distribution in mouse brain, which may have functional significance for the two proteins.
Title: Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain.
Pacrg is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.
Results demonstrate that the deletion of Pacrg (PARKIN-coregulated gene) is the cause of male sterility in the Quaking(viable) (qk(v)) mutant mouse.
Title: Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant.
The quaking mutation is a deletion of approximately 1.17 Mb of mouse chromosome 17, resulting in the deletion of the entire promoter and first five coding exons of PRKN. The recently described Parkin Co-Regulated Gene (PACRG) is completely deleted.
Title: It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG).
PACRG is linked to parkin via a bi-directional promoter [PACRG]
Title: Identification of a novel gene linked to parkin via a bi-directional promoter.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

MHAa59b10.seq (e-PCR)
- UniSTS:125231

Am107b (e-PCR)
- UniSTS:510007

NoName (e-PCR)
- UniSTS:492617

D17Wtc1 (e-PCR), detects polymorphism
- UniSTS:142182

D17Jcs115 (e-PCR), detects polymorphism
- UniSTS:259231

D17Jcs116 (e-PCR), detects polymorphism
- UniSTS:259232

RH128329 (e-PCR)
- UniSTS:211637

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to unfolded protein	TAS Traceable Author Statement more info	PubMed
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in axonemal B tubule inner sheath	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in manchette	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: parkin coregulated gene protein homolog

Names: PARK2 coregulated gene protein; hypertension-related protein 1-like protein; parkin co-regulated gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027032.2 → NP_081308.1 parkin coregulated gene protein homolog

Status: VALIDATED

Source sequence(s)

AK005771, AK135510

Consensus CDS

CCDS28388.1

UniProtKB/Swiss-Prot

Q7TPF9, Q8CG20, Q9DAK2

UniProtKB/TrEMBL

Q0VB91, Q3UXK4

Related

ENSMUSP00000044376.7, ENSMUST00000041463.7

Conserved Domains (2) summary

pfam10274
Location:54 → 237

ParcG; Parkin co-regulated protein

cl21467
Location:19 → 54

Cytochrom_C; Cytochrome c

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

10621938..11059078 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523353.4 → XP_006523416.1 parkin coregulated gene protein homolog isoform X1

Conserved Domains (1) summary

pfam10274
Location:1 → 135

ParcG; Parkin co-regulated protein