Stim1 stromal interaction molecule 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stim1provided by MGI
Official Full Name: stromal interaction molecule 1provided by MGI
Primary source: MGI:MGI:107476
See related: Ensembl:ENSMUSG00000030987 AllianceGenome:MGI:107476
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SIM
Summary: Enables channel regulator activity and identical protein binding activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within establishment of localization in cell; myotube differentiation; and store-operated calcium entry. Located in endoplasmic reticulum. Is active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system gland; and musculature. Used to study Stormorken syndrome and tubular aggregate myopathy 1. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 37.3), testis adult (RPKM 30.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2- E3; 7 54.71 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (101909279..102086525)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102261514..102437319)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries.
Title: Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries.
STIM1-dependent store-operated calcium entry mediates sex differences in macrophage chemotaxis and monocyte recruitment.
Title: STIM1-dependent store-operated calcium entry mediates sex differences in macrophage chemotaxis and monocyte recruitment.
The D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice.
Title: The D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice.
Stromal Interaction Molecule 1 Maintains beta-Cell Identity and Function in Female Mice Through Preservation of G-Protein-Coupled Estrogen Receptor 1 Signaling.
Title: Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein-Coupled Estrogen Receptor 1 Signaling.
Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2.
Title: Chronic suppression of STIM1-mediated calcium signaling in Purkinje cells rescues the cerebellar pathology in spinocerebellar ataxia type 2.
STIM1 ablation impairs exercise-induced physiological cardiac hypertrophy and dysregulates autophagy in mouse hearts.
Title: STIM1 ablation impairs exercise-induced physiological cardiac hypertrophy and dysregulates autophagy in mouse hearts.
Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer's disease.
Title: Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer's disease.
A single amino acid deletion in the ER Ca[2+] sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation.
Title: A single amino acid deletion in the ER Ca(2+) sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation.
CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity.
Title: CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity.
Differential role of STIM1 in calcium handling in coronary and intrarenal arterial smooth muscles.
Title: Differential role of STIM1 in calcium handling in coronary and intrarenal arterial smooth muscles.

Submit: New GeneRIF Correction See all GeneRIFs (159)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (8) 1 citation
Gene trapped (3) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ARHG_57 (e-PCR)
- UniSTS:277012

42.MMHAP90FRF12.seq (e-PCR)
- UniSTS:124476

Stim1 (e-PCR), detects polymorphism
- UniSTS:144516

MGI:1276896 (e-PCR)
- UniSTS:144517

RH126012 (e-PCR)
- UniSTS:162724

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info	PubMed
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables channel activator activity	IDA Inferred from Direct Assay more info	PubMed
enables channel activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables channel activator activity	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in activation of store-operated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in enamel mineralization	ISO Inferred from Sequence Orthology more info
involved_in enamel mineralization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ligand-gated ion channel signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in regulation of store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within store-operated calcium entry	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cortical endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stromal interaction molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374058.1 → NP_001360987.1 stromal interaction molecule 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2), also known as Stim1A (PMID:34942054), contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2, Stim1a, alpha) has a longer C-terminus relative to isoform 1.

Source sequence(s)

AC102535, AC139579

Conserved Domains (3) summary

cd09573
Location:128 → 201

SAM_STIM1; SAM domain of STIM1 subfamily proteins

COG1196
Location:237 → 434

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:344 → 441

SOAR; STIM1 Orai1-activating region
NM_001374060.1 → NP_001360989.1 stromal interaction molecule 1 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3), also known as Stim1b (PMID:33730587), contains an alternate exon, relative to variant 1. The resulting protein (isoform 3, Stim1b) has a shorter and distinct C-terminus relative to isoform 1.

Source sequence(s)

AC102535, AC139579

Consensus CDS

CCDS90292.1

UniProtKB/TrEMBL

A0A1B0GR78

Related

ENSMUSP00000147410.2, ENSMUST00000211457.2

Conserved Domains (3) summary

cd09573
Location:128 → 201

SAM_STIM1; SAM domain of STIM1 subfamily proteins

COG1196
Location:237 → 434

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:344 → 441

SOAR; STIM1 Orai1-activating region
NM_001400557.1 → NP_001387486.1 stromal interaction molecule 1 isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4), also known as Stim1L uses an alternate in frame splice site compared to variant 1. The encoded protein is longer than isoform (1).

Source sequence(s)

AC102535, AC139579

UniProtKB/TrEMBL

A0A1B0GRA5

Related

ENSMUSP00000147443.2, ENSMUST00000209255.2
NM_009287.5 → NP_033313.2 stromal interaction molecule 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_033313.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1

Source sequence(s)

AC102535, AC139579

Consensus CDS

CCDS21530.1

UniProtKB/Swiss-Prot

P70302, Q8K1E1

Related

ENSMUSP00000033289.5, ENSMUST00000033289.6

Conserved Domains (3) summary

cd09573
Location:128 → 201

SAM_STIM1; SAM domain of STIM1 subfamily proteins

COG1196
Location:237 → 434

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:344 → 441

SOAR; STIM1 Orai1-activating region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

101909279..102086525

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152856.1 → XP_036008749.1 stromal interaction molecule 1 isoform X2

Conserved Domains (3) summary

cd09573
Location:54 → 127

SAM_STIM1; SAM domain of STIM1 subfamily proteins

COG1196
Location:163 → 360

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:270 → 367

SOAR; STIM1 Orai1-activating region
XM_036152855.1 → XP_036008748.1 stromal interaction molecule 1 isoform X2

Conserved Domains (3) summary

cd09573
Location:54 → 127

SAM_STIM1; SAM domain of STIM1 subfamily proteins

COG1196
Location:163 → 360

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:270 → 367

SOAR; STIM1 Orai1-activating region
XM_006507536.4 → XP_006507599.1 stromal interaction molecule 1 isoform X3

Conserved Domains (3) summary

cd09573
Location:128 → 201

SAM_STIM1; SAM domain of STIM1 subfamily proteins

COG1196
Location:237 → 434

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:344 → 441

SOAR; STIM1 Orai1-activating region