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    Ino80 INO80 complex subunit [ Mus musculus (house mouse) ]

    Gene ID: 68142, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ino80provided by MGI
    Official Full Name
    INO80 complex subunitprovided by MGI
    Primary source
    MGI:MGI:1915392
    See related
    Ensembl:ENSMUSG00000034154 AllianceGenome:MGI:1915392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Inoc1; 2310079N15Rik; 4632409L19Rik
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; alpha-tubulin binding activity; and histone binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in cytosol and nuclear body. Predicted to be part of Ino80 complex. Is expressed in several structures, including ectoderm; genitourinary system; liver; muscle tissue; and primitive endoderm. Orthologous to human INO80 (INO80 complex ATPase subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 5.8), limb E14.5 (RPKM 5.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ino80 in Genome Data Viewer
    Location:
    2 E5; 2 59.97 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119203523..119308168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119373042..119478685, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14207 Neighboring gene STARR-positive B cell enhancer ABC_E4493 Neighboring gene delta like canonical Notch ligand 4 Neighboring gene STARR-positive B cell enhancer ABC_E1251 Neighboring gene ChaC, cation transport regulator 1 Neighboring gene STARR-seq mESC enhancer starr_05481 Neighboring gene STARR-positive B cell enhancer ABC_E5969 Neighboring gene STARR-seq mESC enhancer starr_05483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:119303641-119303888 Neighboring gene predicted gene, 33412 Neighboring gene cyclin-dependent kinase 12 pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2639 Neighboring gene STARR-positive B cell enhancer ABC_E5970

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables ATP-dependent activity, acting on DNA  
    enables ATP-dependent activity, acting on DNA  
    enables DNA binding  
    enables DNA binding  
    enables DNA clamp loader activity  
    enables actin binding  
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables histone binding  
    Items 1 - 25 of 36
    Process Evidence Code Pubs
    involved_in DNA repair  
    involved_in DNA-templated transcription  
    involved_in UV-damage excision repair  
    involved_in UV-damage excision repair  
    involved_in cell division  
    involved_in cellular response to UV  
    involved_in cellular response to ionizing radiation  
    involved_in cellular response to ionizing radiation  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in double-strand break repair  
    involved_in double-strand break repair via homologous recombination  
    involved_in double-strand break repair via homologous recombination  
    involved_in mitotic sister chromatid segregation  
    involved_in mitotic sister chromatid segregation  
    involved_in positive regulation of DNA repair PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of nuclear cell cycle DNA replication  
    involved_in positive regulation of nuclear cell cycle DNA replication  
    involved_in positive regulation of telomere maintenance in response to DNA damage PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of DNA repair PubMed 
    involved_in regulation of DNA replication  
    involved_in regulation of DNA strand elongation  
    involved_in regulation of G1/S transition of mitotic cell cycle  
    involved_in regulation of G1/S transition of mitotic cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of chromosome organization  
    involved_in regulation of embryonic development PubMed 
    involved_in spindle assembly  
    involved_in spindle assembly  
    involved_in telomere maintenance PubMed 
    Items 1 - 25 of 36
    Component Evidence Code Pubs
    part_of Ino80 complex  
    part_of Ino80 complex  
    located_in cytosol  
    located_in cytosol  
    located_in microtubule  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in spindle  

    General protein information

    Preferred Names
    chromatin-remodeling ATPase INO80
    Names
    DNA helicase INO80
    DNA helicase-related INO80 complex homolog 1
    DNA helicase-related protein INO80
    INO80 complex subunit A
    putative DNA helicase INO80 complex homolog 1
    yeast INO80-like protein
    NP_080850.2
    XP_036018407.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026574.4NP_080850.2  chromatin-remodeling ATPase INO80

      Status: VALIDATED

      Source sequence(s)
      AL844862, AL929318
      Consensus CDS
      CCDS16602.1
      UniProtKB/Swiss-Prot
      A2AQP8, Q6P7V0, Q6PCP1, Q6ZPV2, Q8C9T7
      Related
      ENSMUSP00000051845.8, ENSMUST00000049920.14
      Conserved Domains (3) summary
      COG0553
      Location:3501262
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18002
      Location:520748
      DEXQc_INO80; DEAQ-box helicase domain of INO80
      pfam13892
      Location:275404
      DBINO; DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119203523..119308168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162514.1XP_036018407.1  chromatin-remodeling ATPase INO80 isoform X1

      UniProtKB/Swiss-Prot
      A2AQP8, Q6P7V0, Q6PCP1, Q6ZPV2, Q8C9T7
      Conserved Domains (3) summary
      COG0553
      Location:3501262
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18002
      Location:520748
      DEXQc_INO80; DEAQ-box helicase domain of INO80
      pfam13892
      Location:275404
      DBINO; DNA-binding domain
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