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    Adamtsl5 ADAMTS-like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamtsl5provided by RGD
    Official Full Name
    ADAMTS-like 5provided by RGD
    Primary source
    RGD:1305607
    See related
    EnsemblRapid:ENSRNOG00000033787 AllianceGenome:RGD:1305607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Thsd6
    Summary
    Predicted to enable heparin binding activity and microfibril binding activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region and microfibril. Orthologous to human ADAMTSL5 (ADAMTS like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 51.5), Muscle (RPKM 28.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamtsl5 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10013306..10021924)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9362623..9371248)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12228706..12237382)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member D Neighboring gene polo-like kinase 5 Neighboring gene receptor accessory protein 6 Neighboring gene uncharacterized LOC108351405 Neighboring gene proprotein convertase subtilisin/kexin type 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module. Bader HL, et al. Matrix Biol, 2012 Sep-Oct. PMID 23010571, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microfibril binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADAMTS-like protein 5
    Names
    thrombospondin, type I domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108071.2 → NP_001101541.1  ADAMTS-like protein 5 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001101541.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K8M1, F1M9K2
      Related
      ENSRNOP00000057537.3, ENSRNOT00000060811.6
      Conserved Domains (1) summary
      smart00209
      Location:49 → 98
      TSP1; Thrombospondin type 1 repeats

    2. NM_001400960.1 → NP_001387889.1  ADAMTS-like protein 5 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6GJQ1

    3. NM_001400961.1 → NP_001387890.1  ADAMTS-like protein 5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6GJQ1, A6K8M0
      Related
      ENSRNOP00000108160.1, ENSRNOT00000137487.1

    4. NM_001400962.1 → NP_001387891.1  ADAMTS-like protein 5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000111564.1, ENSRNOT00000141752.1

    5. NM_001400963.1 → NP_001387892.1  ADAMTS-like protein 5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6GJQ1, A6K8M0

    6. NM_001400965.1 → NP_001387894.1  ADAMTS-like protein 5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6GJQ1, A6K8M0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10013306..10021924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078993.2 → XP_038934921.1  ADAMTS-like protein 5 isoform X6

      Conserved Domains (2) summary
      smart00209
      Location:200 → 246
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:444 → 524
      ADAM_spacer1; ADAM-TS Spacer 1

    2. XM_039078986.2 → XP_038934914.1  ADAMTS-like protein 5 isoform X1

      Conserved Domains (3) summary
      smart00209
      Location:200 → 246
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:608 → 707
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:444 → 541
      ADAM_spacer1; ADAM-TS Spacer 1

    3. XM_039078998.2 → XP_038934926.1  ADAMTS-like protein 5 isoform X9

      Conserved Domains (2) summary
      smart00209
      Location:200 → 246
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:368 → 456
      ADAM_spacer1; ADAM-TS Spacer 1

    4. XM_039078987.2 → XP_038934915.1  ADAMTS-like protein 5 isoform X2

      Conserved Domains (3) summary
      smart00209
      Location:200 → 249
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:598 → 697
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:434 → 531
      ADAM_spacer1; ADAM-TS Spacer 1

    5. XM_039078992.2 → XP_038934920.1  ADAMTS-like protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:200 → 246
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:540 → 639
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:368 → 473
      ADAM_spacer1; ADAM-TS Spacer 1

    6. XM_063263416.1 → XP_063119486.1  ADAMTS-like protein 5 isoform X11

    7. XM_039078994.2 → XP_038934922.1  ADAMTS-like protein 5 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:200 → 249
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:530 → 629
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:358 → 463
      ADAM_spacer1; ADAM-TS Spacer 1

    8. XM_039078988.2 → XP_038934916.1  ADAMTS-like protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Related
      ENSRNOP00000092372.2, ENSRNOT00000101922.2
      Conserved Domains (3) summary
      smart00209
      Location:145 → 191
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:553 → 652
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:389 → 486
      ADAM_spacer1; ADAM-TS Spacer 1

    9. XM_039078991.2 → XP_038934919.1  ADAMTS-like protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:142 → 188
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:550 → 649
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:386 → 483
      ADAM_spacer1; ADAM-TS Spacer 1

    10. XM_039078996.2 → XP_038934924.1  ADAMTS-like protein 5 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:116 → 162
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:524 → 623
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:360 → 457
      ADAM_spacer1; ADAM-TS Spacer 1

    11. XM_039078999.2 → XP_038934927.1  ADAMTS-like protein 5 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:49 → 95
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:457 → 556
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:293 → 390
      ADAM_spacer1; ADAM-TS Spacer 1

    12. XM_039079000.2 → XP_038934928.1  ADAMTS-like protein 5 isoform X10

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:49 → 95
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:457 → 556
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:293 → 390
      ADAM_spacer1; ADAM-TS Spacer 1

    13. XM_039078990.2 → XP_038934918.1  ADAMTS-like protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:145 → 191
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:553 → 652
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:389 → 486
      ADAM_spacer1; ADAM-TS Spacer 1

    14. XM_039078989.1 → XP_038934917.1  ADAMTS-like protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GJQ1
      Conserved Domains (3) summary
      smart00209
      Location:145 → 191
      TSP1; Thrombospondin type 1 repeats
      cd03523
      Location:553 → 652
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:389 → 486
      ADAM_spacer1; ADAM-TS Spacer 1

    15. XM_039079002.2 → XP_038934930.1  ADAMTS-like protein 5 isoform X12

      Conserved Domains (3) summary
      cd03523
      Location:356 → 455
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
      pfam05986
      Location:192 → 289
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:16 → 84
      ADAM_CR; ADAM cysteine-rich

    RNA

    1. XR_005486600.2 RNA Sequence

    2. XR_005486599.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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