P2rx7 purinergic receptor P2X 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29665, updated on 9-Dec-2024

Summary

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Symbol: P2rx7provided by RGD
Full Name: purinergic receptor P2X 7provided by RGD
Primary source: RGD:3241
See related: EnsemblRapid:ENSRNOG00000001296 AllianceGenome:RGD:3241
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including ATP binding activity; extracellularly ATP-gated monoatomic cation channel activity; and metal ion binding activity. Involved in several processes, including ATP export; bleb assembly; and positive regulation of macromolecule metabolic process. Located in several cellular components, including bleb; nuclear envelope; and terminal bouton. Part of protein-containing complex. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 74.0), Lung (RPKM 67.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See P2rx7 in Genome Data Viewer

Location:: 12q16

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (39550531..39594984, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (33889709..33934168, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (39353613..39396042, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2X7 receptors exhibit at least three modes of allosteric antagonism.
Title: P2X(7) receptors exhibit at least three modes of allosteric antagonism.
Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors.
Title: Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors.
LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury.
Title: LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury.
Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function.
Title: Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function.
Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7.
Title: Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7.
Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis.
Title: Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis.
Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.
Title: Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.
Ligand-gated ion channel P2X7 regulates NLRP3/Caspase-1-mediated inflammatory pain caused by pulpitis in the trigeminal ganglion and medullary dorsal horn.
Title: Ligand-gated ion channel P2X7 regulates NLRP3/Caspase-1-mediated inflammatory pain caused by pulpitis in the trigeminal ganglion and medullary dorsal horn.
Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCepsilon/P38MAPK/NF-kappaB Signaling Pathway in Rats.
Title: Silencing P2X7R Alleviates Diabetic Neuropathic Pain Involving TRPV1 via PKCε/P38MAPK/NF-κB Signaling Pathway in Rats.
P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling.
Title: P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (211)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139111 (e-PCR)
- UniSTS:221197

RH143493 (e-PCR)
- UniSTS:232740

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables channel activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellularly ATP-gated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellularly ATP-gated monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly ATP-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IC Inferred by Curator more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables purinergic nucleotide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables purinergic nucleotide receptor activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within NAD transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in bleb assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell volume homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collagen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of glutamate secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagolysosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid transfer to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid translocation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within plasma membrane organization	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane phospholipid scrambling	ISO Inferred from Sequence Orthology more info
involved_in pore complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bleb assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lymphocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in purinergic nucleotide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic dense core granule exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ATP	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to electrical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to fluid shear stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle budding from membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bleb	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P2X purinoceptor 7

Names: ATP receptor; P2X purinoceptor 7-like; P2X7 purinoceptor; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019256.2 → NP_062129.1 P2X purinoceptor 7

See identical proteins and their annotated locations for NP_062129.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q64663

UniProtKB/TrEMBL

A6J184, A6J185

Related

ENSRNOP00000094617.1, ENSRNOT00000119858.2

Conserved Domains (1) summary

pfam00864
Location:11 → 393

P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

39550531..39594984 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089304.2 → XP_038945232.1 P2X purinoceptor 7 isoform X1

UniProtKB/TrEMBL

A6J184

Conserved Domains (1) summary

pfam00864
Location:11 → 417

P2X_receptor; ATP P2X receptor
XM_008769223.4 → XP_008767445.1 P2X purinoceptor 7 isoform X3

See identical proteins and their annotated locations for XP_008767445.1

UniProtKB/TrEMBL

A0A8I6ARA0, C8YIX5

Related

ENSRNOP00000001746.7, ENSRNOT00000001746.9

Conserved Domains (2) summary

pfam00864
Location:9 → 394

P2X_receptor; ATP P2X receptor

pfam14473
Location:455 → 514

RD3; RD3 protein
XM_039089305.2 → XP_038945233.1 P2X purinoceptor 7 isoform X2

UniProtKB/TrEMBL

A0A8I6ARA0, A0A8L2Q078

Conserved Domains (1) summary

pfam00864
Location:9 → 414

P2X_receptor; ATP P2X receptor
XM_039089306.2 → XP_038945234.1 P2X purinoceptor 7 isoform X4

Conserved Domains (1) summary

cl02993
Location:3 → 105

P2X_receptor; ATP P2X receptor