Nfkbiz NFKB inhibitor zeta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nfkbizprovided by RGD
Official Full Name: NFKB inhibitor zetaprovided by RGD
Primary source: RGD:1310834
See related: EnsemblRapid:ENSRNOG00000031163 AllianceGenome:RGD:1310834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mail; RGD1310834
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune response; and response to bacterium. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasmic ribonucleoprotein granule and nuclear speck. Predicted to be active in nucleus. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 74.7), Thymus (RPKM 56.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (58251720..58279767)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (44782676..44810722)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (47243342..47271487)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest role for NF-kappaBIZ in age-associated progressive renal fibrosis via cytokine signaling.
Title: Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis.

Submit: New GeneRIF Correction

General gene information

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Markers

BE110884 (e-PCR)
- UniSTS:245325

d11rat67 (e-PCR)
- UniSTS:120786

RH128110 (e-PCR)
- UniSTS:211418

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables POU domain binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-17	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chronic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in isotype switching	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte activation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in plasma cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to cisplatin	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to folic acid	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in skin epidermis development	ISO Inferred from Sequence Orthology more info
involved_in spleen development	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription preinitiation complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NF-kappa-B inhibitor zeta

Names: IkappaB-zeta; molecule possessing ankyrin-repeats induced by lipopolysaccharide; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401430.1 → NP_001388359.1 NF-kappa-B inhibitor zeta

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A0G2K6U7, M5AJR0

Related

ENSRNOP00000073948.2, ENSRNOT00000078856.3
NM_001415136.1 → NP_001402065.1 NF-kappa-B inhibitor zeta

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A0G2K6U7, M5AJR0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

58251720..58279767

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088370.2 → XP_038944298.1 NF-kappa-B inhibitor zeta isoform X1

UniProtKB/TrEMBL

M5AJR0

Conserved Domains (3) summary

PHA03095
Location:421 → 617

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:477 → 535

ANK; ANK repeat [structural motif]

pfam12796
Location:374 → 462

Ank_2; Ankyrin repeats (3 copies)
XM_039088371.2 → XP_038944299.1 NF-kappa-B inhibitor zeta isoform X2

Conserved Domains (2) summary

COG0666
Location:465 → 574

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:468 → 502

ANK; ANK repeat [structural motif]