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    Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 [ Mus musculus (house mouse) ]

    Gene ID: 67464, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Entpd4provided by MGI
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 4provided by MGI
    Primary source
    MGI:MGI:1914714
    See related
    Ensembl:ENSMUSG00000095463 AllianceGenome:MGI:1914714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lysal1; mKIAA0392; 1200014F22Rik; 4930513O14Rik; A430102M06Rik
    Summary
    Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleobase-containing small molecule catabolic process and ribonucleotide metabolic process. Predicted to be located in Golgi membrane and autophagosome membrane. Predicted to be active in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 84.7), kidney adult (RPKM 55.5) and 26 other tissues See more
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    Genomic context

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    See Entpd4 in Genome Data Viewer
    Location:
    14 D2; 14 36.05 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (69574600..69604191)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69337151..69366742)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41197 Neighboring gene syncytin b Neighboring gene predicted gene, 16677 Neighboring gene predicted gene, 53864 Neighboring gene predicted gene, 16867 Neighboring gene predicted gene, 21451 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69896143-69896444 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69903084-69903385 Neighboring gene STARR-seq mESC enhancer starr_37056 Neighboring gene predicted gene 27179 Neighboring gene predicted gene, 41194

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. First apyrase splice variants have different enzymatic properties. Biederbick A, et al. J Biol Chem, 2000 Jun 23. PMID 10858452
    2. Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. Boschen KE, et al. Dis Model Mech, 2021 Jun 1. PMID 34137816, Free PMC Article
    3. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Xiao J, et al. Exp Neurol, 2016 Sep. PMID 27163549, Free PMC Article
    4. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Cui CY, et al. Hum Mol Genet, 2007 Nov 1. PMID 17673451
    5. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables CTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleoside diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CTP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in GDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UDP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleobase-containing small molecule catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleobase-containing small molecule catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 4
    Names
    NTPDase 4
    UDPase
    lysosomal apyrase-like 1
    lysosomal apyrase-like protein of 70 kDa
    uridine-diphosphatase
    NP_001347281.1
    NP_080450.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360352.1 → NP_001347281.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1. This locus is contained within a tandem segmental duplication. This sequence aligns equally well to ectonucleoside triphosphate diphosphohydrolase 4B.
      Source sequence(s)
      AK004761, AK031065, BY276189, CX224148
      UniProtKB/TrEMBL
      Q8CHF7
      Conserved Domains (1) summary
      cl17037
      Location:82 → 532
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_026174.3 → NP_080450.1  ectonucleoside triphosphate diphosphohydrolase 4 isoform 1

      See identical proteins and their annotated locations for NP_080450.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This locus is contained within a tandem segmental duplication. This sequence aligns equally well to ectonucleoside triphosphate diphosphohydrolase 4B.
      Source sequence(s)
      AK004761, AK031065, BY276189
      Consensus CDS
      CCDS27240.1
      UniProtKB/Swiss-Prot
      Q9DBT4
      UniProtKB/TrEMBL
      Q8CHF7
      Related
      ENSMUSP00000138944.2, ENSMUST00000184973.8
      Conserved Domains (1) summary
      cl17037
      Location:82 → 540
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      69574600..69604191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBT4.1 GenPept UniProtKB/Swiss-Prot:Q9DBT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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