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    Dhx38 DEAH-box helicase 38 [ Mus musculus (house mouse) ]

    Gene ID: 64340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhx38provided by MGI
    Official Full Name
    DEAH-box helicase 38provided by MGI
    Primary source
    MGI:MGI:1927617
    See related
    Ensembl:ENSMUSG00000037993 AllianceGenome:MGI:1927617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx38; Prp16; KIAA0224; 5730550P09Rik
    Summary
    Predicted to enable 3'-5' RNA helicase activity and RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in retinitis pigmentosa 84. Orthologous to human DHX38 (DEAH-box helicase 38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.7), CNS E11.5 (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhx38 in Genome Data Viewer
    Location:
    8 D3; 8 57.09 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110274631..110292493, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109547999..109565861, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene predicted gene, 35145 Neighboring gene STARR-seq mESC enhancer starr_22655 Neighboring gene predicted gene, 39246 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112089480-112089589 Neighboring gene STARR-positive B cell enhancer ABC_E565 Neighboring gene thioredoxin-like 4B Neighboring gene haptoglobin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Chu CC, et al. Mol Immunol, 1998 Jun. PMID 9798653
    2. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38
    DEAH (Asp-Glu-Ala-His) box polypeptide 38
    pre-mRNA splicing factor 16
    NP_848467.1
    XP_006531324.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178380.2 → NP_848467.1  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

      See identical proteins and their annotated locations for NP_848467.1

      Status: VALIDATED

      Source sequence(s)
      AC125162, AI503007, BC046557
      Consensus CDS
      CCDS22652.1
      UniProtKB/TrEMBL
      Q6A0A1, Q80X98
      Related
      ENSMUSP00000047865.8, ENSMUST00000042601.9
      Conserved Domains (5) summary
      smart00490
      Location:759 → 862
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:527 → 714
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:931 → 1013
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:552 → 688
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam07717
      Location:1064 → 1147
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RNA

    1. NR_151644.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125162

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110274631..110292493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531261.3 → XP_006531324.1  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1

      UniProtKB/TrEMBL
      Q6A0A1
      Conserved Domains (1) summary
      COG1643
      Location:515 → 1146
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version

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