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    PGS1 Phosphatidylglycerophosphate synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42254, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGS1provided by FlyBase
    Official Full Name
    Phosphatidylglycerophosphate synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038649
    Locus tag
    Dmel_CG7718
    See related
    AllianceGenome:FB:FBgn0038649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7718; Dmel\CG7718; dPGS1; PL D
    Summary
    Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PGS1 in Genome Data Viewer
    Location:
    91C5-91C5; 3-64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18744063..18746041, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14569785..14571763, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Mekk1 Neighboring gene greatwall Neighboring gene ectopic P-granules autophagy protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase. Archambault V, et al. PLoS Genet, 2007 Nov. PMID 17997611, Free PMC Article
    2. Drosophila PTPMT1 Has a Function in Tracheal Air Filling. Papakyrikos AM, et al. iScience, 2020 Jul 24. PMID 32629421, Free PMC Article
    3. Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary. Soshnev AA, et al. Nucleic Acids Res, 2012 Jul. PMID 22406832, Free PMC Article
    4. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
    5. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylglycerophosphate synthase 1
    Names
    CG7718-PA
    PGS1-PA
    phospholipase D
    NP_650751.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18744063..18746041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142494.3 → NP_650751.3  phosphatidylglycerophosphate synthase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650751.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYL0, Q9VE36
      Related
      FBpp0083097
      Conserved Domains (3) summary
      cd09135
      Location:61 → 227
      PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
      cd09137
      Location:289 → 474
      PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases
      pfam13091
      Location:75 → 226
      PLDc_2; PLD-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYL0 Q8SYL0

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