Mp Multiplexin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mpprovided by FlyBase
Official Full Name: Multiplexinprovided by FlyBase
Primary source: FLYBASE:FBgn0260660
Locus tag: Dmel_CG42543
See related: AllianceGenome:FB:FBgn0260660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14822; CG33171; CG42543; CG8645; CG8647; COL18A1; CT14872; Dmel\CG42543; dmp; Dmp; mp; multiplexin
Old locus tag: Dmel_CG33171; Dmel_CG8647
Summary: Predicted to enable carbohydrate binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in several processes, including motor neuron axon guidance; positive regulation of integrin-mediated signaling pathway; and striated muscle atrophy. Predicted to be part of collagen type IV trimer. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including adult heart; embryonic/larval aorta; embryonic/larval dorsal vessel; embryonic/larval heart; and filzkorper. Used to study cardiomyopathy; dilated cardiomyopathy; mitochondrial myopathy; and myopathy. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to several human genes including COL15A1 (collagen type XV alpha 1 chain). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 65D6-65E2; 3-19 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6998843..7053499)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6991943..7046599)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.
Title: Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments.
We further show that the SAGA deubiquitinase-activated gene Multiplexin (Mp) is required in glia for proper photoreceptor axon targeting. Mutations in the human ortholog of Mp, COL18A1, have been identified in a family with a SCA7-like progressive visual disorder, suggesting that defects in the expression of this gene in SCA7 patients could play a role in the retinal degeneration that is unique to this ataxia.
Title: Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development.
The Endostatin domain of Multiplexin is specific for presynaptic homeostasis
Title: Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity.
lack of Mp results in decreased diastolic capacity, leading to reduced heart contractility, as measured in live fly hearts.
Title: Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen.
multiplexin may be involved in establishing the Wingless signaling gradients in the Drosophila embryo
Title: Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0917 (e-PCR)
- UniSTS:28611

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle atrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle atrophy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of collagen type IV trimer	IBA Inferred from Biological aspect of Ancestor more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: multiplexin

Names: CG42543-PB; CG42543-PE; CG42543-PF; CG42543-PG; CG42543-PH; CG42543-PI; CG42543-PJ; CG42543-PL; CG42543-PM; CG42543-PN; CG42543-PO; CG42543-PP; CG42543-PR; CG42543-PS; CG42543-PT; CG42543-PU; Collagen-like; Mp-PB; Mp-PE; Mp-PF; Mp-PG; Mp-PH; Mp-PI; Mp-PJ; Mp-PL; Mp-PM; Mp-PN; Mp-PO; Mp-PP; Mp-PR; Mp-PS; Mp-PT; Mp-PU; collagen XV/XVIII

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6998843..7053499

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300032.1 → NP_001286961.1 multiplexin, isoform T [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

G1API6, X2JC42

Conserved Domains (3) summary

pfam01391
Location:464 → 518

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:814 → 982

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001300033.1 → NP_001286962.1 multiplexin, isoform U [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

G1API6, X2JCL0

Conserved Domains (3) summary

pfam01391
Location:429 → 483

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:764 → 933

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001169887.2 → NP_001163358.1 multiplexin, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JID9, G1API6

Conserved Domains (3) summary

pfam01391
Location:474 → 528

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:815 → 983

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001169893.2 → NP_001163364.1 multiplexin, isoform M [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JIE0, G1API6

Conserved Domains (3) summary

pfam01391
Location:464 → 518

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:810 → 977

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001169892.2 → NP_001163363.1 multiplexin, isoform L [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JIE2, G1API6

Conserved Domains (3) summary

pfam01391
Location:427 → 481

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:762 → 931

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001169890.2 → NP_001163361.1 multiplexin, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JI52

Conserved Domains (2) summary

pfam01391
Location:35 → 89

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:370 → 539

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
NM_001169885.2 → NP_001163356.1 multiplexin, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JIE1, G1API6

Conserved Domains (3) summary

pfam01391
Location:464 → 518

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:799 → 968

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001169891.2 → NP_001163362.2 multiplexin, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JIE3, G1API6

Conserved Domains (3) summary

pfam01391
Location:464 → 518

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:805 → 973

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001259722.1 → NP_001246651.1 multiplexin, isoform R [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

G1API6, M9ND55

Conserved Domains (3) summary

pfam01391
Location:464 → 518

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:831 → 999

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

cl22861
Location:58 → 222

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001300031.1 → NP_001286960.1 multiplexin, isoform S [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

D3DMJ9, X2JGC3

Conserved Domains (2) summary

pfam01391
Location:234 → 288

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:595 → 764

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
NM_176294.5 → NP_788472.2 multiplexin, isoform N [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

D3DMJ9, Q86BH0, Q8MT89

Related

FBpp0291170

Conserved Domains (2) summary

pfam01391
Location:234 → 288

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:584 → 752

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
NM_001169888.2 → NP_001163359.1 multiplexin, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

D3DMJ9, E1JI49

Conserved Domains (2) summary

pfam01391
Location:269 → 323

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:604 → 773

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
NM_001169886.2 → NP_001163357.1 multiplexin, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

D3DMJ9, E1JI50

Conserved Domains (2) summary

pfam01391
Location:234 → 288

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:580 → 747

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
NM_176293.3 → NP_788471.1 multiplexin, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

D3DMJ9, Q86BH1

Related

FBpp0290328

Conserved Domains (2) summary

pfam01391
Location:234 → 288

Collagen; Collagen triple helix repeat (20 copies)

cd00247
Location:569 → 738

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
NM_001169889.2 → NP_001163360.1 multiplexin, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

B2YGG0, E1JI51

Conserved Domains (1) summary

cd00247
Location:50 → 217

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
NM_001259723.1 → NP_001246652.1 multiplexin, isoform P [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

D5AEK4

Conserved Domains (1) summary

cd00247
Location:20 → 189

Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
D5AEK4		D5AEK4
E1JI49		E1JI49
E1JI50		E1JI50
E1JI51		E1JI51
E1JI52		E1JI52
E1JID9		E1JID9
E1JIE0		E1JIE0
E1JIE1		E1JIE1
E1JIE2		E1JIE2
E1JIE3		E1JIE3
M9ND55		M9ND55
Q86BH1		Q86BH1
Q8MSE3		Q8MSE3
Q8MT89		Q8MT89
X2JC42		X2JC42
X2JCL0		X2JCL0
X2JGC3		X2JGC3