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    pths porthos [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35379, updated on 27-Dec-2024

    Summary

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    Official Symbol
    pthsprovided by FlyBase
    Official Full Name
    porthosprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032919
    Locus tag
    Dmel_CG9253
    See related
    AllianceGenome:FB:FBgn0032919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:GressD10; cg9253; CG9253; Dmel\CG9253; DmRH24
    Summary
    Enables rRNA binding activity. Involved in positive regulation of ribosome biogenesis and ribosome biogenesis. Is active in nucleolus. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; head epidermis primordium; larval muscle cell; and trunk visceral muscle primordium. Orthologous to human DDX47 (DEAD-box helicase 47). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pths in Genome Data Viewer
    Location:
    39A4-39A4; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21143229..21145146)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21143229..21145146)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44056 Neighboring gene uncharacterized protein Neighboring gene Na[+]/H[+] hydrogen exchanger 2 Neighboring gene Dynamin associated protein 160 Neighboring gene ncRNA Neighboring gene deadlock Neighboring gene E2F transcription factor 2 Neighboring gene M-phase phosphoprotein 6 Neighboring gene Coenzyme Q3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hybridization fingerprinting of high-density cDNA-library arrays with cDNA pools derived from whole tissues. Gress TM, et al. Mamm Genome, 1992. PMID 1450511
    2. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Martin ET, et al. Dev Cell, 2022 Apr 11. PMID 35413237, Free PMC Article
    3. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Marie B, et al. Neuron, 2004 Jul 22. PMID 15260957
    4. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. Emtenani S, et al. EMBO J, 2022 Jun 14. PMID 35319107, Free PMC Article
    5. Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos. Ota R, et al. Sci Rep, 2021 Mar 1. PMID 33649478, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of positive regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    porthos
    Names
    CG9253-PA
    pths-PA
    NP_610090.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21143229..21145146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136246.3 → NP_610090.1  porthos [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIF6
      UniProtKB/TrEMBL
      Q8MRB7
      Related
      FBpp0080997
      Conserved Domains (3) summary
      COG0513
      Location:34 → 498
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:274 → 403
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:63 → 264
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRB7 Q8MRB7
    Q9VIF6.1 Q9VIF6

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