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    Hacd2 3-hydroxyacyl-CoA dehydratase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hacd2provided by FlyBase
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032524
    Locus tag
    Dmel_CG9267
    See related
    AllianceGenome:FB:FBgn0032524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9267; Dmel\CG9267; HADC[CG9267]; Q9VJX8
    Summary
    Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Orthologous to several human genes including HACD3 (3-hydroxyacyl-CoA dehydratase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hacd2 in Genome Data Viewer
    Location:
    34C1-34C1; 2-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13444103..13445651, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13444103..13445651, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45683 Neighboring gene tehao Neighboring gene Heat shock protein 60D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. Garcia-Ranea JA, et al. FEBS Lett, 2002 Oct 9. PMID 12372593
    2. Advances in deciphering the genetic basis of insect cuticular hydrocarbon biosynthesis and variation. Holze H, et al. Heredity (Edinb), 2021 Feb. PMID 33139902, Free PMC Article
    3. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
    4. Functional dissection of an innate immune response by a genome-wide RNAi screen. Foley E, et al. PLoS Biol, 2004 Aug. PMID 15221030, Free PMC Article
    5. Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. Wicker-Thomas C, et al. J Lipid Res, 2015 Nov. PMID 26353752, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyacyl-CoA dehydratase 2
    Names
    CG9267-PA
    Hacd2-PA
    NP_609655.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13444103..13445651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135811.3 → NP_609655.2  3-hydroxyacyl-CoA dehydratase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609655.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYI0, Q9VJX8
      Related
      FBpp0080097
      Conserved Domains (2) summary
      cd06465
      Location:6 → 114
      p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
      pfam04387
      Location:197 → 357
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYI0 Q8SYI0
    Q9VJX8 Q9VJX8

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