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    CG4537 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4537provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032153
    Locus tag
    Dmel_CG4537
    See related
    AllianceGenome:FB:FBgn0032153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4537
    Summary
    Predicted to enable PDZ domain binding activity and microtubule binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be active in dendrite. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human CRIPT (CXXC repeat containing interactor of PDZ3 domain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4537 in Genome Data Viewer
    Location:
    30E1-30E1; 2-37 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9890885..9891336)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9890885..9891336)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44701 Neighboring gene FK506-binding protein 59kD Neighboring gene uncharacterized protein Neighboring gene mitochondrial DNA helicase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U snoRNA host gene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic screening of the genes interacting with Drosophila FIG4 identified a novel link between CMT-causing gene and long noncoding RNAs. Muraoka Y, et al. Exp Neurol, 2018 Dec. PMID 30165075
    2. Drosophila models to study causative genes for human rare intractable neurological diseases. Yamaguchi M, et al. Exp Cell Res, 2021 Jun 1. PMID 33812867
    3. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
    4. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables PDZ domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4537-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9890885..9891336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103665.2 → NP_001097135.1  uncharacterized protein Dmel_CG4537 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V600, Q9VL77
      Conserved Domains (1) summary
      pfam10235
      Location:11 → 95
      Cript; Microtubule-associated protein CRIPT
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL77 Q9VL77

    Gene LinkOut

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