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    Dus1 Dihydrouridine synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dus1provided by FlyBase
    Official Full Name
    Dihydrouridine synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031238
    Locus tag
    Dmel_CG3645
    See related
    AllianceGenome:FB:FBgn0031238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3645; Dmel\CG3645
    Summary
    Predicted to enable tRNA-dihydrouridine16 synthase activity and tRNA-dihydrouridine17 synthase activity. Predicted to be involved in tRNA processing. Is expressed in organism. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dus1 in Genome Data Viewer
    Location:
    21B5-21B7; 2-0.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (252589..271744, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (252589..271744, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kismet Neighboring gene long non-coding RNA:CR44218 Neighboring gene RNaseP protein p30 Neighboring gene long non-coding RNA:CR44219 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mushroom body miniature

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of dihydrouridine synthases. Kasprzak JM, et al. BMC Bioinformatics, 2012 Jun 28. PMID 22741570, Free PMC Article
    2. Identification of mushroom body miniature, a zinc-finger protein implicated in brain development of Drosophila. Raabe T, et al. Proc Natl Acad Sci U S A, 2004 Sep 28. PMID 15375215, Free PMC Article
    3. Drosophila mini-white model system: new insights into positive position effects and the role of transcriptional terminators and gypsy insulator in transgene shielding. Silicheva M, et al. Nucleic Acids Res, 2010 Jan. PMID 19854952, Free PMC Article
    4. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
    5. Phenotypes Associated with Second Chromosome P Element Insertions in Drosophila melanogaster. Kahsai L, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317776, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dihydrouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-dihydrouridine16 synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA-dihydrouridine17 synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dihydrouridine synthase 1
    Names
    CG3645-PA
    CG3645-PB
    CG3645-PC
    Dus1-PA
    Dus1-PB
    Dus1-PC
    NP_001259809.1
    NP_608507.1
    NP_722619.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      252589..271744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134663.4 → NP_608507.1  dihydrouridine synthase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P2, Q9VPM1
      Related
      FBpp0077799
      Conserved Domains (3) summary
      TIGR01623
      Location:426 → 460
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:29 → 259
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:31 → 303
      Dus; Dihydrouridine synthase (Dus)

    2. NM_164377.3 → NP_722619.1  dihydrouridine synthase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P2, Q9VPM1
      Related
      FBpp0077800
      Conserved Domains (3) summary
      TIGR01623
      Location:426 → 460
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:29 → 259
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:31 → 303
      Dus; Dihydrouridine synthase (Dus)

    3. NM_001272880.1 → NP_001259809.1  dihydrouridine synthase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960P2, Q9VPM1
      Conserved Domains (3) summary
      TIGR01623
      Location:426 → 460
      put_zinc_LRP1; putative zinc finger domain, LRP1 type
      cd02801
      Location:29 → 259
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
      pfam01207
      Location:31 → 303
      Dus; Dihydrouridine synthase (Dus)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPM1 Q9VPM1

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