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    chp chaoptin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chpprovided by FlyBase
    Official Full Name
    chaoptinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267435
    Locus tag
    Dmel_CG1744
    See related
    AllianceGenome:FB:FBgn0267435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    24B10; 516; BSH; CG1744; Chaoptin; Chp; CHP; CT5040; Dmel\CG1744; idl-A; mAb 24B10; MAb 24B10; mAb24B10; mAB24B10; Mab24B10; MAb24B10; Nsp
    Summary
    Involved in homophilic cell adhesion via plasma membrane adhesion molecules; microvillus organization; and rhabdomere development. Located in plasma membrane and rhabdomere microvillus. Is expressed in several structures, including Bolwig nerve; Bolwig organ; adult head; photoreceptor neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See chp in Genome Data Viewer
    Location:
    100B5-100B6; 3-102 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31204180..31210730, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27029902..27036452, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mesh Neighboring gene bottleneck Neighboring gene uncharacterized protein Neighboring gene zwilch Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila chaoptin, a member of the leucine-rich repeat family, is a photoreceptor cell-specific adhesion molecule. Krantz DE, et al. EMBO J, 1990 Jun. PMID 2189727, Free PMC Article
    2. From monoclonal antibody to gene for a neuron-specific glycoprotein in Drosophila. Zipursky SL, et al. Proc Natl Acad Sci U S A, 1985 Mar. PMID 3920657, Free PMC Article
    3. Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes. Zipursky SL, et al. Cell, 1984 Jan. PMID 6420071
    4. Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human. Reinke R, et al. Cell, 1988 Jan 29. PMID 3124963
    5. Monoclonal antibodies against the Drosophila nervous system. Fujita SC, et al. Proc Natl Acad Sci U S A, 1982 Dec. PMID 6818557, Free PMC Article

    See all (255) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glycosylphosphatidylinositol -mannosyltransferase 2 is required for the GPI-mediated membrane attachment of several Glycosylphosphatidylinositol -anchored proteins, including the photoreceptor-specific cell adhesion molecule, chaoptin
      Title: Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin.
    2. N-linked glycosylation of Chp is essential for its stability and activity.
      Title: N-Glycosylation of the Drosophila neural protein Chaoptin is essential for its stability, cell surface transport and adhesive activity.
    3. Spacemaker, a secreted protein expressed only in the eyes of insects with open rhabdom systems, acts together with Prominin and the cell adhesion molecule Chaoptin to choreograph the partitioning of rhabdomeres into an open system.
      Title: Transforming the architecture of compound eyes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microvillus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rhabdomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rhabdomere microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chaoptin
    Names
    CG1744-PA
    CG1744-PC
    CG1744-PD
    CG1744-PE
    CG1744-PF
    INAD localization-A
    Neural-specific-protein
    chaoptic
    chp-PA
    chp-PC
    chp-PD
    chp-PE
    chp-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31204180..31210730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276207.1 → NP_001263136.1  chaoptin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263136.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHG5, F0JAL7
      Conserved Domains (4) summary
      cd00116
      Location:121 → 254
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:419 → 443
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:518 → 541
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:566 → 626
      LRR_8; Leucine rich repeat

    2. NM_001276205.1 → NP_001263134.1  chaoptin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI35, F0JAL7
      Conserved Domains (3) summary
      cd00116
      Location:121 → 254
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:521 → 544
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:569 → 629
      LRR_8; Leucine rich repeat

    3. NM_001276206.1 → NP_001263135.1  chaoptin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHK5, F0JAL7
      Conserved Domains (4) summary
      cd00116
      Location:128 → 261
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:426 → 450
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:755 → 778
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:573 → 633
      LRR_8; Leucine rich repeat

    4. NM_001276208.1 → NP_001263137.1  chaoptin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263137.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHX5, F0JAL7
      Conserved Domains (4) summary
      cd00116
      Location:128 → 261
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:426 → 450
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:525 → 548
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:573 → 633
      LRR_8; Leucine rich repeat

    5. NM_079866.3 → NP_524605.1  chaoptin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12024, Q9VA01
      UniProtKB/TrEMBL
      F0JAG8, F0JAL7
      Related
      FBpp0085139
      Conserved Domains (3) summary
      cd00116
      Location:128 → 261
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:528 → 551
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:576 → 636
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHG5 A0A0B4KHG5
    A0A0B4KHK5 A0A0B4KHK5
    A0A0B4KHX5 A0A0B4KHX5
    A0A0B4KI35 A0A0B4KI35
    P12024.2 P12024

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