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    porin porin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34500, updated on 27-Dec-2024

    Summary

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    Official Symbol
    porinprovided by FlyBase
    Official Full Name
    porinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004363
    Locus tag
    Dmel_CG6647
    See related
    AllianceGenome:FB:FBgn0004363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO02059370.56; cg6647; CG6647; Dmel\CG6647; DmPorin1; DmVDAC; DVDAC; l(2)k05123; POR-1; Porin; PORIN; Vdac; VDAC; Vdac1; VDAC1
    Summary
    Enables voltage-gated monoatomic anion channel activity. Involved in several processes, including negative regulation of calcium import into the mitochondrion; sperm individualization; and sperm mitochondrion organization. Located in Nebenkern and mitochondrion. Is active in mitochondrial outer membrane. Is expressed in several structures, including embryonic/larval midgut primordium; follicle cell; gonad; head epidermis primordium; and trunk visceral muscle primordium. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including VDAC1 (voltage dependent anion channel 1) and VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See porin in Genome Data Viewer
    Location:
    32B1-32B1; 2-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10847227..10850848, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10847227..10850848, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Porin2 Neighboring gene SET and MYND domain containing, arthropod-specific, member 3 Neighboring gene DNZDHHC/NEW1 zinc finger protein 11 Neighboring gene aurora B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mitochondrial porin from Drosophila melanogaster. De Pinto V, et al. Biochim Biophys Acta, 1989 Dec 11. PMID 2480813
    2. Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs. Leggio L, et al. Sci Rep, 2018 Mar 28. PMID 29593233, Free PMC Article
    3. Cloning and molecular characterization of a voltage-dependent anion-selective channel (VDAC) from Drosophila melanogaster. Ryerse J, et al. Biochim Biophys Acta, 1997 Jul 25. PMID 9271262
    4. Cloning and chromosomal localization of a cDNA encoding a mitochondrial porin from Drosophila melanogaster. Messina A, et al. FEBS Lett, 1996 Apr 8. PMID 8797793
    5. Sequence and expression pattern of the Drosophila melanogaster mitochondrial porin gene: evidence of a conserved protein domain between fly and mouse. Oliva M, et al. FEBS Lett, 1998 Jul 3. PMID 9688565

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The inhibition of porin phenocopies Parkinson disease phenotypes in Drosophila, while the overexpression of Buffy can counteract these phenotypes to improve the overall "healthspan" of the organism.
      Title: Loss of porin function in dopaminergic neurons of Drosophila is suppressed by Buffy.
    2. Drosophila porin mutants have a role in mitochondrial dysfunction and disease
      Title: Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease.
    3. Porin isoform 1 is selectively targeted to follicular cells while Porin isoform 2 is present in mitochondria of the epithelial sheath cells of the ovariole.
      Title: Porin isoform 2 has a different localization in Drosophila melanogaster ovaries than porin 1.
    4. Our data suggest that the PORIN protein is important in maintaining a photoreceptor response during prolonged stimulation.
      Title: Effects of a mutation in the Drosophila porin gene encoding mitochondrial voltage-dependent anion channel protein on phototransduction.
    5. identification of two PlacW insertions in the porin gene among a set of P-element insertions that have been mapped to the 32B3-4 region on the second chromosome
      Title: A genetic analysis of the porin gene encoding a voltage-dependent anion channel protein in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of calcium import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Nebenkern IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    porin
    Names
    CG6647-PA
    CG6647-PB
    CG6647-PC
    CG6647-PD
    CG6647-PE
    VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL
    mitochondrial porin
    porin 1
    porin-PA
    porin-PB
    porin-PC
    porin-PD
    porin-PE
    voltage-dependent anion channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10847227..10850848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134283.2 → NP_599110.1  porin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QZ3, Q94920, Q94997, Q9VKP1
      UniProtKB/TrEMBL
      M9PD75
      Related
      FBpp0079772, FBtr0080183
      Conserved Domains (1) summary
      cd07306
      Location:3 → 281
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    2. NM_001259032.1 → NP_001245961.1  porin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245961.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QZ3, Q94920, Q94997, Q9VKP1
      UniProtKB/TrEMBL
      M9PD75
      Conserved Domains (1) summary
      cd07306
      Location:3 → 281
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    3. NM_001273436.1 → NP_001260365.1  porin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QZ3, Q94920, Q94997, Q9VKP1
      UniProtKB/TrEMBL
      M9PD75
      Conserved Domains (1) summary
      cd07306
      Location:3 → 281
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    4. NM_001038810.2 → NP_001033899.1  porin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033899.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QZ3, Q94920, Q94997, Q9VKP1
      UniProtKB/TrEMBL
      M9PD75
      Conserved Domains (1) summary
      cd07306
      Location:3 → 281
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    5. NM_057465.4 → NP_476813.1  porin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476813.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QZ3, Q94920, Q94997, Q9VKP1
      UniProtKB/TrEMBL
      M9PD75
      Related
      FBpp0079771
      Conserved Domains (1) summary
      cd07306
      Location:3 → 281
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD75 M9PD75
    Q94920.3 Q94920

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