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    Tecpr2 tectonin beta-propeller repeat containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314456, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tecpr2provided by RGD
    Official Full Name
    tectonin beta-propeller repeat containing 2provided by RGD
    Primary source
    RGD:1307503
    See related
    EnsemblRapid:ENSRNOG00000021904 AllianceGenome:RGD:1307503
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307503
    Summary
    Predicted to be involved in protein exit from endoplasmic reticulum. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 49. Orthologous to human TECPR2 (tectonin beta-propeller repeat containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 82.6), Adrenal (RPKM 53.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tecpr2 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (135720765..135823187)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (129899541..130001975)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (135304536..135405865)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351302 Neighboring gene transfer RNA isoleucine (anticodon AAU) 3 Neighboring gene zinc finger protein 839 Neighboring gene cyclin-dependent kinase 2-interacting protein Neighboring gene uncharacterized LOC134479258 Neighboring gene ankyrin repeat domain 9 Neighboring gene uncharacterized LOC134479478

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export. Stadel D, et al. Mol Cell, 2015 Oct 1. PMID 26431026
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein exit from endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tectonin beta-propeller repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427221.1 → NP_001414150.1  tectonin beta-propeller repeat-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D4A6U4
      Related
      ENSRNOP00000035369.5, ENSRNOT00000030864.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      135720765..135823187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262024.1 → XP_063118094.1  tectonin beta-propeller repeat-containing protein 2 isoform X2

      Related
      ENSRNOP00000103146.1, ENSRNOT00000142113.1

    2. XM_063262025.1 → XP_063118095.1  tectonin beta-propeller repeat-containing protein 2 isoform X5

    3. XM_006240620.4 → XP_006240682.1  tectonin beta-propeller repeat-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006240682.1

      Related
      ENSRNOP00000099871.1, ENSRNOT00000128256.1
      Conserved Domains (2) summary
      pfam06462
      Location:864 → 894
      Hyd_WA; Propeller
      pfam19193
      Location:1046 → 1240
      Tectonin; Tectonin domain

    4. XM_039113381.2 → XP_038969309.1  tectonin beta-propeller repeat-containing protein 2 isoform X3

      Conserved Domains (2) summary
      pfam06462
      Location:864 → 894
      Hyd_WA; Propeller
      pfam19193
      Location:1046 → 1240
      Tectonin; Tectonin domain

    5. XM_008764970.4 → XP_008763192.1  tectonin beta-propeller repeat-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008763192.1

      UniProtKB/TrEMBL
      D4A6U4
      Conserved Domains (4) summary
      COG2319
      Location:36 → 366
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:37 → 73
      7WD40; WD40 repeat [structural motif]
      pfam06462
      Location:1003 → 1033
      Hyd_WA; Propeller
      pfam19193
      Location:1185 → 1379
      Tectonin; Tectonin domain

    6. XM_039113382.2 → XP_038969310.1  tectonin beta-propeller repeat-containing protein 2 isoform X3

      Conserved Domains (2) summary
      pfam06462
      Location:864 → 894
      Hyd_WA; Propeller
      pfam19193
      Location:1046 → 1240
      Tectonin; Tectonin domain

    7. XM_039113379.2 → XP_038969307.1  tectonin beta-propeller repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      D4A6U4
      Conserved Domains (4) summary
      COG2319
      Location:36 → 366
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:37 → 73
      7WD40; WD40 repeat [structural motif]
      pfam06462
      Location:1003 → 1033
      Hyd_WA; Propeller
      pfam19193
      Location:1185 → 1379
      Tectonin; Tectonin domain

    8. XM_008764972.4 → XP_008763194.1  tectonin beta-propeller repeat-containing protein 2 isoform X3

      See identical proteins and their annotated locations for XP_008763194.1

      Conserved Domains (2) summary
      pfam06462
      Location:864 → 894
      Hyd_WA; Propeller
      pfam19193
      Location:1046 → 1240
      Tectonin; Tectonin domain

    9. XM_039113383.2 → XP_038969311.1  tectonin beta-propeller repeat-containing protein 2 isoform X4

      Conserved Domains (2) summary
      pfam06462
      Location:636 → 666
      Hyd_WA; Propeller
      pfam19193
      Location:818 → 1012
      Tectonin; Tectonin domain

    RNA

    1. XR_010052098.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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