Traf3 Tnf receptor-associated factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Traf3provided by RGD
Official Full Name: Tnf receptor-associated factor 3provided by RGD
Primary source: RGD:1304633
See related: EnsemblRapid:ENSRNOG00000008145 AllianceGenome:RGD:1304633
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including regulation of defense response; regulation of type I interferon production; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be part of CD40 receptor complex. Predicted to be active in endosome membrane and mitochondrion. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF receptor associated factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 119.1), Spleen (RPKM 80.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (136025097..136128363)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (130199696..130307168)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (135610698..135720247)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALKBH5-mediated m6A demethylation of pri-miR-199a-5p exacerbates myocardial ischemia/reperfusion injury by regulating TRAF3-mediated pyroptosis.
Title: ALKBH5-mediated m6A demethylation of pri-miR-199a-5p exacerbates myocardial ischemia/reperfusion injury by regulating TRAF3-mediated pyroptosis.
Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination.
Title: Ubiquitin-specific protease 11 Aggravates Ischemia-reperfusion-induced Cardiomyocyte Pyroptosis and Injury by Promoting TRAF3 Deubiquitination.
Protective Effect of miR-193a-5p and miR-320-5p on Caerulein-Induced Injury in AR42J Cells.
Title: Protective Effect of miR-193a-5p and miR-320-5p on Caerulein-Induced Injury in AR42J Cells.
TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.
Title: TRAF3, a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells.
Rela and Traf3 were both targeted by miR-155-5p.
Title: miR-155-5p is Negatively Associated with Acute Pancreatitis and Inversely Regulates Pancreatic Acinar Cell Progression by Targeting Rela and Traf3.
Data indicate a striking upregulation of TNF receptor associated factor 3 (TRAF3) after spinal cord injury (SCI).
Title: Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury.
Dominant-negative forms of TRAF2 and TRAF3 inhibited but did not fully block LMP1-mediated transformation.
Title: Unique signaling properties of CTAR1 in LMP1-mediated transformation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

TRAF3_1584 (e-PCR)
- UniSTS:277842

TRAF3_v555 (e-PCR)
- UniSTS:277842

d6rat101 (e-PCR)
- UniSTS:122194

AI528849 (e-PCR)
- UniSTS:185960

BE119065 (e-PCR)
- UniSTS:249080

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CD40 receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of plasma membrane signaling receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TNF receptor-associated factor 3

NP_001382041.1

EC 2.3.2.27

XP_038968511.1

EC 2.3.2.27

XP_038968512.1

EC 2.3.2.27

XP_038968513.1

EC 2.3.2.27

XP_038968516.1

EC 2.3.2.27

XP_038968517.1

EC 2.3.2.27

XP_038968518.1

EC 2.3.2.27

XP_038968519.1

EC 2.3.2.27

XP_038968520.1

EC 2.3.2.27

XP_063118217.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395112.1 → NP_001382041.1 TNF receptor-associated factor 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

136025097..136128363

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112591.2 → XP_038968519.1 TNF receptor-associated factor 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_039112585.2 → XP_038968513.1 TNF receptor-associated factor 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0

Related

ENSRNOP00000111538.1, ENSRNOT00000127387.1

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_039112589.2 → XP_038968517.1 TNF receptor-associated factor 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0

Related

ENSRNOP00000010906.6, ENSRNOT00000010906.8

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_039112588.2 → XP_038968516.1 TNF receptor-associated factor 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_039112592.2 → XP_038968520.1 TNF receptor-associated factor 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_039112590.2 → XP_038968518.1 TNF receptor-associated factor 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0

Conserved Domains (5) summary

COG1196
Location:251 → 432

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:377 → 562

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:135 → 191

zf-TRAF; TRAF-type zinc finger

cd16640
Location:50 → 91

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:196 → 246

zf-TRAF; TRAF-type zinc finger
XM_063262147.1 → XP_063118217.1 TNF receptor-associated factor 3 isoform X3

UniProtKB/TrEMBL

A0A8I6ARU4, A6KBQ0, D3Z9G0
XM_039112583.2 → XP_038968511.1 TNF receptor-associated factor 3 isoform X1

UniProtKB/TrEMBL

A0A0G2K7X2, A0A8I6ARU4

Related

ENSRNOP00000074381.1, ENSRNOT00000077770.3

Conserved Domains (5) summary

COG1196
Location:294 → 475

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:420 → 605

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:178 → 234

zf-TRAF; TRAF-type zinc finger

cd16640
Location:93 → 134

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

cl40617
Location:239 → 289

zf-TRAF; TRAF-type zinc finger
XM_039112584.2 → XP_038968512.1 TNF receptor-associated factor 3 isoform X2

UniProtKB/TrEMBL

A0A8I6ARU4

Related

ENSRNOP00000094542.2, ENSRNOT00000108306.2

Conserved Domains (4) summary

COG1196
Location:269 → 450

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd03777
Location:395 → 580

MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...

pfam02176
Location:178 → 234

zf-TRAF; TRAF-type zinc finger

cd16640
Location:93 → 134

RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108724.2: Suppressed sequence

Description

NM_001108724.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.