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    Gtf2f1 general transcription factor IIF, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 98053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtf2f1provided by MGI
    Official Full Name
    general transcription factor IIF, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1923848
    See related
    Ensembl:ENSMUSG00000002658 AllianceGenome:MGI:1923848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAP74; 2810405L04Rik
    Summary
    Predicted to enable several functions, including RNA polymerase II general transcription initiation factor activity; TFIIF-class transcription factor complex binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIF complex. Is expressed in genitourinary system. Orthologous to human GTF2F1 (general transcription factor IIF subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 78.6), liver E14 (RPKM 38.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf2f1 in Genome Data Viewer
    Location:
    17 D; 17 29.62 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57310402..57318398, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57003401..57011394, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E491 Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene STARR-positive B cell enhancer ABC_E492 Neighboring gene adenylate kinase 5 pseudogene Neighboring gene KH-type splicing regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TFIIF facilitates dissociation of RNA polymerase II from noncoding RNAs that lack a repression domain. Wagner SD, et al. Mol Cell Biol, 2010 Jan. PMID 19841064, Free PMC Article
    2. Structure-function analysis of Msx2-mediated transcriptional suppression. Newberry EP, et al. Biochemistry, 1997 Aug 26. PMID 9265625
    3. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article
    4. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II general transcription initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TFIIF-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables promoter-specific chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIF complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIF subunit 1
    Names
    TFIIF-alpha
    general transcription factor IIF polypeptide 1 (74kD subunit)
    transcription initiation factor IIF subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419459.1 → NP_001406388.1  general transcription factor IIF subunit 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    2. NM_001419461.1 → NP_001406390.1  general transcription factor IIF subunit 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    3. NM_001419463.1 → NP_001406392.1  general transcription factor IIF subunit 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    4. NM_001419464.1 → NP_001406393.1  general transcription factor IIF subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    5. NM_001419465.1 → NP_001406394.1  general transcription factor IIF subunit 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    6. NM_001419466.1 → NP_001406395.1  general transcription factor IIF subunit 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    7. NM_001419467.1 → NP_001406396.1  general transcription factor IIF subunit 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    8. NM_001419468.1 → NP_001406397.1  general transcription factor IIF subunit 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    9. NM_001419469.1 → NP_001406398.1  general transcription factor IIF subunit 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    10. NM_001419470.1 → NP_001406399.1  general transcription factor IIF subunit 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    11. NM_001419471.1 → NP_001406400.1  general transcription factor IIF subunit 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    12. NM_001419472.1 → NP_001406401.1  general transcription factor IIF subunit 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    13. NM_001419473.1 → NP_001406402.1  general transcription factor IIF subunit 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    14. NM_001419474.1 → NP_001406403.1  general transcription factor IIF subunit 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    15. NM_001419475.1 → NP_001406404.1  general transcription factor IIF subunit 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    16. NM_001419476.1 → NP_001406405.1  general transcription factor IIF subunit 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    17. NM_001419477.1 → NP_001406406.1  general transcription factor IIF subunit 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    18. NM_133801.3 → NP_598562.1  general transcription factor IIF subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_598562.1

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247
      Consensus CDS
      CCDS37667.1
      UniProtKB/Swiss-Prot
      Q3THK3, Q8R5B7
      Related
      ENSMUSP00000002733.7, ENSMUST00000002733.7
      Conserved Domains (1) summary
      pfam05793
      Location:2 → 508
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

    RNA

    1. NR_185085.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073683, CT571247

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57310402..57318398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3THK3.2 GenPept UniProtKB/Swiss-Prot:Q3THK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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