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    Xpo6 exportin 6 [ Mus musculus (house mouse) ]

    Gene ID: 74204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xpo6provided by MGI
    Official Full Name
    exportin 6provided by MGI
    Primary source
    MGI:MGI:2429950
    See related
    Ensembl:ENSMUSG00000000131 AllianceGenome:MGI:2429950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    exp6; Ranbp20; mKIAA0370; 2610005L19Rik; C230091E20Rik
    Summary
    Predicted to enable nuclear export signal receptor activity. Involved in protein export from nucleus. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human XPO6 (exportin 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 61.3), thymus adult (RPKM 29.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xpo6 in Genome Data Viewer
    Location:
    7 F3; 7 69.01 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125700890..125799715, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126101718..126200539, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene katanin interacting protein Neighboring gene VISTA enhancer mm174 Neighboring gene STARR-seq mESC enhancer starr_20126 Neighboring gene GSG1-like Neighboring gene predicted gene, 51456 Neighboring gene STARR-seq mESC enhancer starr_20127 Neighboring gene STARR-seq mESC enhancer starr_20131 Neighboring gene LAG1 homolog, ceramide synthase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20132 Neighboring gene RIKEN cDNA 1700123J17 gene Neighboring gene STARR-seq mESC enhancer starr_20133 Neighboring gene STARR-seq mESC enhancer starr_20134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133373927-133374110 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes. Wu Y, et al. Int Immunopharmacol, 2024 Jun 30. PMID 38788453
    2. Active maintenance of nuclear actin by importin 9 supports transcription. Dopie J, et al. Proc Natl Acad Sci U S A, 2012 Feb 28. PMID 22323606, Free PMC Article
    3. ZMPSTE24 defends against influenza and other pathogenic viruses. Fu B, et al. J Exp Med, 2017 Apr 3. PMID 28246125, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exportin XPO6 upregulation activates the TLR2/MyD88/NF-kappaB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes.
      Title: Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes.
    2. Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6.
      Title: Active maintenance of nuclear actin by importin 9 supports transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exportin-6
    Names
    RAN binding protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311143.2 → NP_001298072.1  exportin-6 isoform 1

      See identical proteins and their annotated locations for NP_001298072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC012297, AC135809
      Consensus CDS
      CCDS80800.1
      UniProtKB/Swiss-Prot
      Q3U3K7, Q6PEF3, Q924Z6, Q9D0K9
      Related
      ENSMUSP00000130527.2, ENSMUST00000168189.8
      Conserved Domains (2) summary
      smart00913
      Location:31 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103 → 277
      Xpo1; Exportin 1-like protein

    2. NM_028816.3 → NP_083092.2  exportin-6 isoform 2

      See identical proteins and their annotated locations for NP_083092.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC135809, BC058090, BU708634
      Consensus CDS
      CCDS52396.1
      UniProtKB/Swiss-Prot
      Q924Z6
      Related
      ENSMUSP00000009344.10, ENSMUST00000009344.16
      Conserved Domains (2) summary
      smart00913
      Location:31 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103 → 277
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      125700890..125799715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312342.3 → XP_017167831.1  exportin-6 isoform X2

      Conserved Domains (2) summary
      smart00913
      Location:31 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103 → 277
      Xpo1; Exportin 1-like protein

    2. XM_017312341.3 → XP_017167830.1  exportin-6 isoform X1

      Conserved Domains (2) summary
      smart00913
      Location:31 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:103 → 277
      Xpo1; Exportin 1-like protein

    3. XM_006508250.2 → XP_006508313.1  exportin-6 isoform X4

      UniProtKB/TrEMBL
      Q8CHG0

    4. XM_036153494.1 → XP_036009387.1  exportin-6 isoform X5

      UniProtKB/TrEMBL
      Q8CHG0

    5. XM_036153493.1 → XP_036009386.1  exportin-6 isoform X3

      UniProtKB/TrEMBL
      Q8CHG0

    6. XM_017312345.3 → XP_017167834.1  exportin-6 isoform X6

      UniProtKB/TrEMBL
      Q8CHG0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924Z6.2 GenPept UniProtKB/Swiss-Prot:Q924Z6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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