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    Npepps aminopeptidase puromycin sensitive [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50558, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Npeppsprovided by RGD
    Official Full Name
    aminopeptidase puromycin sensitiveprovided by RGD
    Primary source
    RGD:619962
    See related
    EnsemblRapid:ENSRNOG00000023095 AllianceGenome:RGD:619962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Psa
    Summary
    Enables aminopeptidase activity. Predicted to be involved in several processes, including cellular response to hypoxia; peptide catabolic process; and positive regulation of protein targeting to mitochondrion. Predicted to be active in cytosol; extracellular space; and membrane. Orthologous to human NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 150.6), Heart (RPKM 125.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Npepps in Genome Data Viewer
    Location:
    10q31
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82687869..82770363, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82191454..82273967, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85140368..85222861, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TBK1 binding protein 1 Neighboring gene karyopherin subunit beta 1 Neighboring gene uncharacterized LOC134480862 Neighboring gene uncharacterized LOC134480863 Neighboring gene mitochondrial ribosomal protein L45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development. Hui M, et al. Neurochem Res, 2003 Jun. PMID 12718438
    2. cDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate? Huber G, et al. J Neurochem, 1999 Mar. PMID 10037494
    3. Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment. Mitani T, et al. J Steroid Biochem Mol Biol, 2011 Jan. PMID 21056661
    4. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. Beninga J, et al. J Biol Chem, 1998 Jul 24. PMID 9668046
    5. Two new proteases in the MHC class I processing pathway. Stoltze L, et al. Nat Immunol, 2000 Nov. PMID 11062501

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a study of the levels in rat cerebellar development
      Title: Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    puromycin-sensitive aminopeptidase
    NP_536320.1
    XP_017452967.1
    XP_038942585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080395.1 → NP_536320.1  puromycin-sensitive aminopeptidase

      Status: VALIDATED

      Source sequence(s)
      AB062596, BC105844, CA503636, CA510536, CA512355, DV216619, DY316730, H32677
      UniProtKB/TrEMBL
      A6HIJ7, F1M9V7
      Related
      ENSRNOP00000033290.4, ENSRNOT00000031045.7
      Conserved Domains (3) summary
      cd09601
      Location:62 → 505
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:54 → 442
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:580 → 891
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82687869..82770363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597478.2 → XP_017452967.1  puromycin-sensitive aminopeptidase isoform X1

      UniProtKB/TrEMBL
      A6HIJ7
      Conserved Domains (2) summary
      cd09601
      Location:1 → 344
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:423 → 736
      ERAP1_C; ERAP1-like C-terminal domain

    2. XM_039086657.2 → XP_038942585.1  puromycin-sensitive aminopeptidase isoform X1

      UniProtKB/TrEMBL
      A6HIJ7
      Conserved Domains (2) summary
      cd09601
      Location:1 → 344
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:423 → 736
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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