Mcub mitochondrial calcium uniporter dominant negative subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcubprovided by RGD
Official Full Name: mitochondrial calcium uniporter dominant negative subunit betaprovided by RGD
Primary source: RGD:1305326
See related: EnsemblRapid:ENSRNOG00000009433 AllianceGenome:RGD:1305326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc109b; RGD1305326
Summary: Predicted to enable calcium channel inhibitor activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; negative regulation of calcium import into the mitochondrion; and positive regulation of skeletal muscle satellite cell differentiation. Predicted to be located in mitochondrial inner membrane and nucleoplasm. Predicted to be part of uniplex complex. Orthologous to human MCUB (mitochondrial calcium uniporter dominant negative subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 31.0), Lung (RPKM 27.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (221153525..221223814, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (218479301..218549594, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (235353506..235356936, complement) , (230198346..230274033, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel inhibitor activity	ISO Inferred from Sequence Orthology more info
NOT enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle satellite cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium uniporter regulatory subunit MCUb, mitochondrial

Names: coiled-coil domain containing 109B; coiled-coil domain-containing protein 109B; mitochondrial calcium uniporter dominant negative beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398673.1 → NP_001385602.1 calcium uniporter regulatory subunit MCUb, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HVQ8, F1LUQ0

Related

ENSRNOP00000012586.8, ENSRNOT00000012587.9

Conserved Domains (1) summary

pfam04678
Location:102 → 304

MCU; Mitochondrial calcium uniporter