Cpne8 copine 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpne8provided by RGD
Official Full Name: copine 8provided by RGD
Primary source: RGD:1307939
See related: EnsemblRapid:ENSRNOG00000026128 AllianceGenome:RGD:1307939
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be active in plasma membrane. Orthologous to human CPNE8 (copine 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Liver (RPKM 49.3), Heart (RPKM 38.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q35

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (123494864..123669060, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (121615293..121789507, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (131623180..131798236, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF413659 (e-PCR)
- UniSTS:248581

RH129441 (e-PCR)
- UniSTS:212748

d7mit24 (e-PCR)
- UniSTS:120504

D7Got130 (e-PCR)
- UniSTS:115416

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: copine-8

Names: copine 8 protein; copine VIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108750.1 → NP_001102220.1 copine-8

Status: PROVISIONAL

Source sequence(s)

CH474027

UniProtKB/TrEMBL

A0A8I6GJF1, B5DEX3, F7EN58

Related

ENSRNOP00000037093.4, ENSRNOT00000039857.6

Conserved Domains (3) summary

cd04047
Location:171 → 282

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:37 → 158

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:292 → 548

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...