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    Gpr89b G protein-coupled receptor 89B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362003, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gpr89bprovided by RGD
    Official Full Name
    G protein-coupled receptor 89Bprovided by RGD
    Primary source
    RGD:1304837
    See related
    EnsemblRapid:ENSRNOG00000000095 AllianceGenome:RGD:1304837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr89; RGD1304837
    Summary
    Predicted to enable voltage-gated monoatomic anion channel activity. Predicted to be involved in intracellular pH reduction and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in Golgi-associated vesicle membrane. Predicted to be active in Golgi cisterna membrane. Orthologous to several human genes including GPR89B (G protein-coupled receptor 89B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 130.5), Kidney (RPKM 125.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr89b in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187096970..187134391, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184408136..184445560, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198999945..199038702, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene CD160 molecule Neighboring gene PDZ domain containing 1 Neighboring gene gap junction protein, alpha 8 Neighboring gene Fcf1 rRNA-processing protein, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier. Tarutani M, et al. J Invest Dermatol, 2012 Aug. PMID 22572823
    2. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Maeda Y, et al. Nat Cell Biol, 2008 Oct. PMID 18794847
    3. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular pH reduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular pH reduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in skin development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor 89

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139486.1 → NP_001132958.1  G protein-coupled receptor 89

      Status: VALIDATED

      Source sequence(s)
      BC166718, CO387870, DY546285, DY548897
      UniProtKB/TrEMBL
      A6K3A0, F1LTD0
      Related
      ENSRNOP00000000106.5, ENSRNOT00000000106.8
      Conserved Domains (2) summary
      pfam12430
      Location:276 → 444
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:140 → 207
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      187096970..187134391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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