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    Itpkb inositol-trisphosphate 3-kinase B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54260, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Itpkbprovided by RGD
    Official Full Name
    inositol-trisphosphate 3-kinase Bprovided by RGD
    Primary source
    RGD:2932
    See related
    EnsemblRapid:ENSRNOG00000002969 AllianceGenome:RGD:2932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IP3K B
    Summary
    Predicted to enable inositol hexakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in cellular response to calcium ion; inositol phosphate metabolic process; and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 121.6), Thymus (RPKM 107.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itpkb in Genome Data Viewer
    Location:
    13q26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (94601072..94696180)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (92069160..92164281)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98615287..98710426)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553289 Neighboring gene uncharacterized LOC120096326 Neighboring gene uncharacterized LOC108352582 Neighboring gene stum, mechanosensory transduction mediator homolog Neighboring gene uncharacterized LOC120096327

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis. Yu JC, et al. Biochem J, 2005 Dec 15. PMID 16173920, Free PMC Article
    2. Isolation and sequence of a full length cDNA encoding a novel rat inositol 1,4,5-trisphosphate 3-kinase. Thomas S, et al. Biochim Biophys Acta, 1994 Jan 13. PMID 8312366
    3. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Jia Y, et al. Proc Natl Acad Sci U S A, 2008 Mar 25. PMID 18339802, Free PMC Article
    4. Identification and subcellular distribution of endogenous Ins(1,4,5)P(3) 3-kinase B in mouse tissues. Hascakova-Bartova R, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381088
    5. Inositol (1,4,5) trisphosphate 3 kinase B controls positive selection of T cells and modulates Erk activity. Wen BG, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15064401, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The localization and activity of inositol 1,4,5-trisphosphate 3-kinase B(IP3KB) and its modulation by proteolysis are reported.
      Title: Regulation of the localization and activity of inositol 1,4,5-trisphosphate 3-kinase B in intact cells by proteolysis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within common myeloid progenitor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol trisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inositol trisphosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within myeloid cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within thymic T cell selection ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol-trisphosphate 3-kinase B
    Names
    IP3 3-kinase B
    IP3K-B
    inositol 1,4,5-trisphosphate 3-kinase B
    insP 3-kinase B
    NP_062185.2
    XP_038946953.1
    XP_038946954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019312.2 → NP_062185.2  inositol-trisphosphate 3-kinase B

      See identical proteins and their annotated locations for NP_062185.2

      Status: VALIDATED

      Source sequence(s)
      AA859368, AJ242781, BE113255, BF418570
      UniProtKB/Swiss-Prot
      P42335, Q91XW1
      UniProtKB/TrEMBL
      A6JGG8
      Related
      ENSRNOP00000004032.5, ENSRNOT00000004032.8
      Conserved Domains (1) summary
      pfam03770
      Location:714 → 925
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      94601072..94696180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091025.2 → XP_038946953.1  inositol-trisphosphate 3-kinase B isoform X1

    2. XM_039091026.2 → XP_038946954.1  inositol-trisphosphate 3-kinase B isoform X2

      Conserved Domains (1) summary
      pfam03770
      Location:99 → 310
      IPK; Inositol polyphosphate kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42335.3 GenPept UniProtKB/Swiss-Prot:P42335

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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