Clec14a C-type lectin domain family 14, member a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec14aprovided by MGI
Official Full Name: C-type lectin domain family 14, member aprovided by MGI
Primary source: MGI:MGI:1914114
See related: Ensembl:ENSMUSG00000045930 AllianceGenome:MGI:1914114
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200003C23Rik
Summary: Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Involved in cell migration involved in sprouting angiogenesis. Acts upstream of or within with a positive effect on vascular endothelial growth factor receptor-3 signaling pathway. Acts upstream of or within with a negative effect on vascular endothelial growth factor receptor-2 signaling pathway. Acts upstream of or within lymphangiogenesis and sprouting angiogenesis. Located in collagen-containing extracellular matrix. Is expressed in bladder; central nervous system; and embryo mesenchyme. Orthologous to human CLEC14A (C-type lectin domain containing 14A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 25.65 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (58311506..58316044, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (58264720..58269258, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.
Title: CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.
CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation.
Title: CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation.
Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein.
Title: Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein.
CLEC14A acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 signaling in endothelial cells
Title: Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
clec14a-CTLD may be a key domain in angiogenesis
Title: Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro.
These findings demonstrate that Clec14a is a novel endothelial cells specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
Title: Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236854

AI642649 (e-PCR)
- UniSTS:180395

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix protein binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect vascular endothelial growth factor receptor-2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect vascular endothelial growth factor receptor-3 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 14 member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.