Fmnl1 formin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fmnl1provided by MGI
Official Full Name: formin-like 1provided by MGI
Primary source: MGI:MGI:1888994
See related: Ensembl:ENSMUSG00000055805 AllianceGenome:MGI:1888994
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fmnl; Fnrl; Frls; 8030453N10Rik
Summary: Enables several functions, including GTPase activating protein binding activity; profilin binding activity; and small GTPase binding activity. Involved in actin filament severing. Acts upstream of or within substrate-dependent cell migration. Located in cytosol; phagocytic vesicle; and plasma membrane. Is expressed in several structures, including gut; heart; immune system; liver; and lung. Orthologous to human FMNL1 (formin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 65.2), spleen adult (RPKM 49.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 66.71 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (103061401..103089727)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (103171004..103198902)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity.
Title: Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity.
FMNL1 is required for actin assembly on lipid droplets (LDs) in vitro and for NMIIa recruitment to LDs in cells. We propose a novel acto-myosin structure regulating lipid storage: FMNL1-dependent assembly of myosin II-functionalized actin filaments on LDs facilitates their dissociation, thereby affecting LD surface-to-volume ratio and enzyme accessibility to triglycerides.
Title: Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.
In oocyte meiosis, FMNL1 is required for spindle organization and actin assembly.
Title: RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis.
Depleting FMNL1, another Formin family member, resulted in reduced mDia1 expression, while RhoA inhibition did not alter mDia1 expression, which indicated that there was a FMNL1-mDia1-Profilin1 signaling pathway in mouse oocytes.
Title: Formin mDia1, a downstream molecule of FMNL1, regulates Profilin1 for actin assembly and spindle organization during mouse oocyte meiosis.
FMNL1 and FMNL2 are required non-redundantly in the repair of damaged myofibrils.
Title: Critical roles for multiple formins during cardiac myofibril development and repair.
In vitro rheologic assays were used to deconvolve the dynamic cross-linking activity from the bundling activity of formin FRL1 and the closely related mDia1 and mDia2.
Title: The filamentous actin cross-linking/bundling activity of mammalian formins.
A new allele of limb deformity is described due to complete deletion of Fmn1, including its global control region.
Title: Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.
the bundling activities of FRL1 and mDia2, while producing phenotypically similar bundles, differ in mechanistic detail
Title: Mechanistic differences in actin bundling activity of two mammalian formins, FRL1 and mDia2.
Binding to interphase microtubules through exon-2-encoded domain of Fmn1 provides a novel mechanism by which Fmn1 isoform Ib could coordinate actin filaments and microtubules.
Title: Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI553564 (e-PCR)
- UniSTS:185920

FMNL1_8237 (e-PCR)
- UniSTS:468421

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activating protein binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activating protein binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables profilin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament severing	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within substrate-dependent cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: formin-like protein 1

Names: formin-related gene in leukocytes; formin-related protein; lymphocyte specific formin related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077698.2 → NP_001071166.1 formin-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_001071166.1

Status: VALIDATED

Source sequence(s)

AL662804

Consensus CDS

CCDS36348.1

UniProtKB/Swiss-Prot

Q6KAN4, Q9JL26, Q9Z2V7

Related

ENSMUSP00000046296.6, ENSMUST00000042286.12

Conserved Domains (3) summary

pfam02181
Location:628 → 993

FH2; Formin Homology 2 Domain

pfam06367
Location:283 → 432

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:28 → 280

Drf_GBD; Diaphanous GTPase-binding Domain
NM_001403612.1 → NP_001390541.1 formin-like protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL662804
NM_001403613.1 → NP_001390542.1 formin-like protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL662804
NM_001403614.1 → NP_001390543.1 formin-like protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL662804
NM_001403615.1 → NP_001390544.1 formin-like protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL662804

UniProtKB/TrEMBL

A0A1W2P6X3

Related

ENSMUSP00000151439.2, ENSMUST00000218163.2
NM_001403616.1 → NP_001390545.1 formin-like protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL662804
NM_001403617.1 → NP_001390546.1 formin-like protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL662804
NM_001403618.1 → NP_001390547.1 formin-like protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AL662804
NM_019679.3 → NP_062653.2 formin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_062653.2

Status: VALIDATED

Source sequence(s)

AL662804

Consensus CDS

CCDS36349.1

UniProtKB/TrEMBL

A2AB60

Related

ENSMUSP00000102642.3, ENSMUST00000107027.9

Conserved Domains (3) summary

pfam02181
Location:628 → 993

FH2; Formin Homology 2 Domain

pfam06367
Location:283 → 432

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:28 → 280

Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

103061401..103089727

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533839.4 → XP_006533902.1 formin-like protein 1 isoform X3

Conserved Domains (3) summary

pfam02181
Location:647 → 1012

FH2; Formin Homology 2 Domain

pfam06367
Location:302 → 451

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:28 → 299

Drf_GBD; Diaphanous GTPase-binding Domain
XM_006533840.4 → XP_006533903.1 formin-like protein 1 isoform X4

Conserved Domains (3) summary

pfam02181
Location:646 → 1011

FH2; Formin Homology 2 Domain

pfam06367
Location:302 → 451

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:28 → 299

Drf_GBD; Diaphanous GTPase-binding Domain
XM_006533845.4 → XP_006533908.1 formin-like protein 1 isoform X10

Conserved Domains (3) summary

pfam02181
Location:576 → 941

FH2; Formin Homology 2 Domain

pfam06367
Location:231 → 380

Drf_FH3; Diaphanous FH3 Domain

pfam06371
Location:28 → 228

Drf_GBD; Diaphanous GTPase-binding Domain