Plcl2 phospholipase C-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plcl2provided by MGI
Official Full Name: phospholipase C-like 2provided by MGI
Primary source: MGI:MGI:1352756
See related: Ensembl:ENSMUSG00000038910 AllianceGenome:MGI:1352756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Plce2; PLC-L2; PRIP-2; mKIAA1092
Summary: Predicted to enable GABA receptor binding activity and phosphatidylinositol phospholipase C activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human PLCL2 (phospholipase C like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 8.5), CNS E18 (RPKM 6.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 25.86 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (50815893..50995522)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (50508865..50688494)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.
Title: Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.
These results suggest that PRIPs are positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion.
Title: Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development.
Suppressed expression of PRIP-2 induces an elevated expression of KCC2 in the spinal cord, resulting in inhibition of nociception and amelioration of neuropathic pain in DKO mice.
Title: Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice.
The results suggest that PRIP2 is involved in insulin-induced GABA(A) receptor insertion by recruiting active Akt to the receptor complex.
Title: Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.
PLC-L2 is a novel negative regulator of BCR signaling and immune responses
Title: Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plcl2 (e-PCR), detects polymorphism
- UniSTS:507156

D17Mit270 (e-PCR), detects polymorphism
- UniSTS:142141

UniSTS:237662 (e-PCR)
- UniSTS:237662

PLCL2_9323 (e-PCR)
- UniSTS:468603

RH131115 (e-PCR)
- UniSTS:214398

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GABA receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell proliferation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B-1a B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of receptor binding	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive phospholipase C-like protein 2

Names: PLC-L(2); PLC-epsilon-2; phospholipase C, epsilon 2; phospholipase C-L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013880.3 → NP_038908.2 inactive phospholipase C-like protein 2

See identical proteins and their annotated locations for NP_038908.2

Status: VALIDATED

Source sequence(s)

AB033615, AK134985, AK137821, BE983099, BY125070, CD553464

Consensus CDS

CCDS28875.1

UniProtKB/Swiss-Prot

Q3U4E2, Q80TK5, Q8K394, Q9QYG1

Related

ENSMUSP00000046584.7, ENSMUST00000043938.8

Conserved Domains (4) summary

cd00275
Location:754 → 882

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08597
Location:426 → 722

PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein

cd13364
Location:144 → 252

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16223
Location:272 → 415

EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

50815893..50995522

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524151.4 → XP_006524214.1 inactive phospholipase C-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006524214.1

UniProtKB/Swiss-Prot

Q3U4E2, Q80TK5, Q8K394, Q9QYG1

Conserved Domains (4) summary

cd00275
Location:754 → 882

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08597
Location:426 → 722

PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein

cd13364
Location:144 → 252

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16223
Location:272 → 415

EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
XM_036160552.1 → XP_036016445.1 inactive phospholipase C-like protein 2 isoform X2

Conserved Domains (4) summary

cd00275
Location:754 → 882

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08597
Location:426 → 722

PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein

cd13364
Location:144 → 252

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16223
Location:272 → 415

EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
XM_006524152.4 → XP_006524215.1 inactive phospholipase C-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006524215.1

UniProtKB/Swiss-Prot

Q3U4E2, Q80TK5, Q8K394, Q9QYG1

Conserved Domains (4) summary

cd00275
Location:754 → 882

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08597
Location:426 → 722

PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein

cd13364
Location:144 → 252

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16223
Location:272 → 415

EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)
XM_006524150.4 → XP_006524213.1 inactive phospholipase C-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006524213.1

UniProtKB/Swiss-Prot

Q3U4E2, Q80TK5, Q8K394, Q9QYG1

Conserved Domains (4) summary

cd00275
Location:754 → 882

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08597
Location:426 → 722

PI-PLCc_PRIP_metazoa; Catalytic domain of metazoan phospholipase C related, but catalytically inactive protein

cd13364
Location:144 → 252

PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain

cd16223
Location:272 → 415

EFh_PRIP2; EF-hand motif found in phospholipase C-related but catalytically inactive protein 2 (PRIP-2)