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    Zfp296 zinc finger protein 296 [ Mus musculus (house mouse) ]

    Gene ID: 63872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp296provided by MGI
    Official Full Name
    zinc finger protein 296provided by MGI
    Primary source
    MGI:MGI:1926956
    See related
    Ensembl:ENSMUSG00000011267 AllianceGenome:MGI:1926956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf296; 2210018A16Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in spermatogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including bone marrow; central nervous system; early conceptus; gonad; and ureter. Orthologous to human ZNF296 (zinc finger protein 296). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 14.0), ovary adult (RPKM 6.4) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp296 in Genome Data Viewer
    Location:
    7 A3; 7 9.93 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19311212..19314581)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19577287..19580656)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 37 Neighboring gene STARR-seq mESC enhancer starr_18207 Neighboring gene gem nuclear organelle associated protein 7 Neighboring gene CLK4-associating serine/arginine rich protein Neighboring gene avian reticuloendotheliosis viral (v-rel) oncogene related B Neighboring gene STARR-positive B cell enhancer ABC_E1720

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells. Miyazaki S, et al. Commun Biol, 2023 Jul 24. PMID 37488353, Free PMC Article
    2. NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells. Kloet SL, et al. Nat Commun, 2018 Nov 2. PMID 30389936, Free PMC Article
    3. The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells. Mizoue Y, et al. Int J Dev Biol, 2023. PMID 38334180
    4. Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Hackett JA, et al. Nat Commun, 2018 Oct 16. PMID 30327475, Free PMC Article
    5. Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator. Fujii Y, et al. Biochem Biophys Res Commun, 2013 Nov 15. PMID 24161396

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells.
      Title: The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells.
    2. Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells.
      Title: Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells.
    3. The results demonstrate that Zfp296 is a component of heterochromatin that affects embryonic development by negatively regulating H3K9 methylation.
      Title: Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.
    4. ZFP296 was identified as an embryonic stem cell-specific NuRD interactor that also interacts with the SIN3A complex.
      Title: NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells.
    5. Zfp296 is a key component of an expanded primordial germ cells gene regulatory network.
      Title: Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.
    6. These findings suggest that Zfp296 is a functional regulator of Klf4 in embryonic stem cells.
      Title: Zfp296 is a novel Klf4-interacting protein and functions as a negative regulator.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 296
    Names
    hepatocellular carcinoma-associated antigen MHCA108

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022409.2 → NP_071854.2  zinc finger protein 296

      Status: VALIDATED

      Source sequence(s)
      AK008748, BE634620, BE635089, DV647330
      Consensus CDS
      CCDS52060.1
      UniProtKB/Swiss-Prot
      E9Q6W4, Q4FZI6, Q9D7X0, Q9EPM0
      Related
      ENSMUSP00000104093.2, ENSMUST00000108453.2
      Conserved Domains (5) summary
      COG5048
      Location:361 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:362 → 382
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:214 → 234
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:361 → 382
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:226 → 251
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19311212..19314581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q6W4.1 GenPept UniProtKB/Swiss-Prot:E9Q6W4

    Gene LinkOut

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