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    Eef1b2 eukaryotic translation elongation factor 1 beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 55949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eef1b2provided by MGI
    Official Full Name
    eukaryotic translation elongation factor 1 beta 2provided by MGI
    Primary source
    MGI:MGI:1929520
    See related
    Ensembl:ENSMUSG00000025967 AllianceGenome:MGI:1929520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eef1b; EF-1-beta; 2810017J07Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and translation elongation factor activity. Predicted to be involved in response to ethanol and translational elongation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Predicted to colocalize with endoplasmic reticulum. Is expressed in several structures, including brain; exocrine gland; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 172.4), liver E14 (RPKM 139.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eef1b2 in Genome Data Viewer
    Location:
    1 C2; 1 32.31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63215990..63219645)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63176831..63180486)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit D Neighboring gene ribosomal protein S27, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2545 Neighboring gene STARR-seq mESC enhancer starr_01125 Neighboring gene INO80 complex subunit D, opposite strand Neighboring gene STARR-seq mESC enhancer starr_01129 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S1 Neighboring gene STARR-positive B cell enhancer ABC_E1994 Neighboring gene STARR-positive B cell enhancer ABC_E3279 Neighboring gene STARR-seq mESC enhancer starr_01131 Neighboring gene predicted gene, 26457 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene STARR-seq mESC enhancer starr_01132 Neighboring gene chemerin chemokine-like receptor 2 Neighboring gene STARR-seq mESC enhancer starr_01135 Neighboring gene zinc finger, DBF-type containing 2 Neighboring gene RIKEN cDNA 1700039I01 gene Neighboring gene STARR-seq mESC enhancer starr_01137

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling. Feng S, et al. Cell Mol Life Sci, 2024 Jun 15. PMID 38878096, Free PMC Article
    2. Molecular cloning and tissue expression analysis of the beta subunit of elongation factor 1 in the mouse. Liu Q, et al. Biochem Genet, 2000 Apr. PMID 11100270
    3. Proteome analysis of mouse brain: two-dimensional electrophoresis profiles of tissue proteins during the course of aging. Tsugita A, et al. Electrophoresis, 2000 May. PMID 10870971
    4. The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals. Duffié R, et al. Genes Dev, 2014 Mar 1. PMID 24589776, Free PMC Article
    5. Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. Shu H, et al. Mol Cell Proteomics, 2004 Mar. PMID 14729942

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/beta-catenin signaling.
      Title: EEF1B2 regulates bone marrow-derived mesenchymal stem cells bone-fat balance via Wnt/β-catenin signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    elongation factor 1-beta
    Names
    eukaryotic translation elongation factor 1-beta homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018796.3 → NP_061266.2  elongation factor 1-beta

      See identical proteins and their annotated locations for NP_061266.2

      Status: VALIDATED

      Source sequence(s)
      AK027911, AL645950
      Consensus CDS
      CCDS14997.1
      UniProtKB/Swiss-Prot
      O70251, Q3THP5, Q5SUH1, Q8CHS1, Q99L22, Q9CZD4
      UniProtKB/TrEMBL
      A0A087WS46
      Related
      ENSMUSP00000116492.2, ENSMUST00000129339.8
      Conserved Domains (3) summary
      cd10308
      Location:3 → 62
      GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
      pfam00736
      Location:142 → 225
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:103 → 130
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      63215990..63219645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70251.5 GenPept UniProtKB/Swiss-Prot:O70251

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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