Ppa1 pyrophosphatase (inorganic) 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppa1provided by MGI
Official Full Name: pyrophosphatase (inorganic) 1provided by MGI
Primary source: MGI:MGI:97831
See related: Ensembl:ENSMUSG00000020089 AllianceGenome:MGI:97831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pyp; 2010317E03Rik
Summary: Enables pyrophosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; cranium; integumental system; sensory organ; and telencephalon. Orthologous to human PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 58.9), CNS E18 (RPKM 48.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.25 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (61484400..61509944)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (61648621..61674165)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PPA1 promotes adipogenesis by regulating the stability of C/EBPs.
Title: PPA1 promotes adipogenesis by regulating the stability of C/EBPs.
Cold-inducible PPA1 is critical for the adipocyte browning in mice.
Title: Cold-inducible PPA1 is critical for the adipocyte browning in mice.
PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARgamma Target Gene.
Title: PPA1 Regulates Systemic Insulin Sensitivity by Maintaining Adipocyte Mitochondria Function as a Novel PPARγ Target Gene.
PPA1 may play a role in neuronal differentiation via JNK dephosphorylation.
Title: Regulation of neurite growth by inorganic pyrophosphatase 1 via JNK dephosphorylation.
IRBIT opposes the effects of WNKs and SPAK by recruiting PP1 to the complex to dephosphorylate CFTR and NBCe1-B, restoring their cell surface expression, in addition to stimulating their activities
Title: IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inorganic diphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables pyrophosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphate-containing compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphate-containing compound metabolic process	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inorganic pyrophosphatase

Names: PPase; pyrophosphate phospho-hydrolase

NP_080714.2

EC 3.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026438.4 → NP_080714.2 inorganic pyrophosphatase

See identical proteins and their annotated locations for NP_080714.2

Status: PROVISIONAL

Source sequence(s)

AC124421

Consensus CDS

CCDS23882.1

UniProtKB/Swiss-Prot

Q9D819

UniProtKB/TrEMBL

Q3UA53, Q4FK49

Related

ENSMUSP00000020286.7, ENSMUST00000020286.7

Conserved Domains (1) summary

cl00217
Location:4 → 241

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.