Csnk2b casein kinase 2, beta polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csnk2bprovided by MGI
Official Full Name: casein kinase 2, beta polypeptideprovided by MGI
Primary source: MGI:MGI:88548
See related: Ensembl:ENSMUSG00000024387 AllianceGenome:MGI:88548
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CK II beta
Summary: This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression: Broad expression in testis adult (RPKM 540.1), duodenum adult (RPKM 75.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.59 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35335171..35341029, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35116195..35122053, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta.
Title: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β.
Results found that the regulatory CK2 beta subunits are essential for GN11 neuronal cell migration and their deletion induces deep changes in cytoskeletal structures that totally prevent cell migration.
Title: Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.
pool of ecto-CK2 is not apparently affected by the lack of the beta-subunit
Title: A proteomics analysis of CK2β((-/-)) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit.
Ablation of Ck2beta gene triggered excessive germ cell apoptosis, germ cell development arrest, azoospermia and male infertility. Inactivation of Ck2beta gene caused distinctly reduced expression of Ck2alpha' gene and CK2alpha' protein.
Title: Deletion of Ck2β gene causes germ cell development arrest and azoospermia in male mice.
Oocyte-specific deletion of CK2beta causes follicular atresia and premature ovarian failure in mice.
Title: Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure.
GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of mouse neurons.
Title: Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes.
thrombotic vascular occlusion in vivo was significantly blunted in ck2beta(-/-) mice, accompanied by a slight prolongation of bleeding time
Title: CK2β regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis.
AMPKalpha signalling suppresses EMT and secretion of chemokines in renal tubular epithelia through interaction with CK2beta to attenuate renal injury.
Title: AMPKα2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with CK2β.
These data suggest that CK2 is a negative regulator of BMP signaling and osteoblast differentiation.
Title: Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling.
Data suggest that CK2beta appears to play an essential and uncompensated role in central nervous system development.
Title: Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137048 (e-PCR)
- UniSTS:219137

RH129972 (e-PCR)
- UniSTS:213260

MARC_3347-3348:966881404:1 (e-PCR)
- UniSTS:231017

MARC_3347-3348:991937077:1 (e-PCR)
- UniSTS:231017

Csnk2b (e-PCR), detects polymorphism
- UniSTS:141422

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in symbiont-mediated disruption of host cell PML body	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in PML body	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IEA Inferred from Electronic Annotation more info
part_of protein kinase CK2 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: casein kinase II subunit beta

Names: phosvitin

NP_001290374.1

EC 2.7.11.1

NP_001290375.1

EC 2.7.11.1

NP_001290405.1

EC 2.7.11.1

NP_034105.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303445.1 → NP_001290374.1 casein kinase II subunit beta isoform 2

See identical proteins and their annotated locations for NP_001290374.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

CR974444

Consensus CDS

CCDS28684.1

UniProtKB/Swiss-Prot

P67871, Q3TTJ7

UniProtKB/TrEMBL

N0E4C0

Related

ENSMUSP00000134218.2, ENSMUST00000173114.8

Conserved Domains (1) summary

smart01085
Location:8 → 191

CK_II_beta; Casein kinase II regulatory subunit
NM_001303446.1 → NP_001290375.1 casein kinase II subunit beta isoform 1

See identical proteins and their annotated locations for NP_001290375.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

CR974444

UniProtKB/TrEMBL

N0E4C0

Related

ENSMUSP00000134523.3, ENSMUST00000172765.9

Conserved Domains (1) summary

smart01085
Location:29 → 212

CK_II_beta; Casein kinase II regulatory subunit
NM_001303476.1 → NP_001290405.1 casein kinase II subunit beta isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains multiple differences in the 5' UTR and coding region compared to variant 1, including initiation of translation at a downstream start codon. It encodes isoform 3, which is longer than isoform 1 and has a shorter N-terminus and a distinct C-terminus.

Source sequence(s)

CR974444

Consensus CDS

CCDS79541.1

UniProtKB/TrEMBL

G3UZX4

Related

ENSMUSP00000134673.2, ENSMUST00000174024.8

Conserved Domains (1) summary

smart01085
Location:8 → 129

CK_II_beta; Casein kinase II regulatory subunit
NM_009975.3 → NP_034105.1 casein kinase II subunit beta isoform 2

See identical proteins and their annotated locations for NP_034105.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).

Source sequence(s)

CR974444

Consensus CDS

CCDS28684.1

UniProtKB/Swiss-Prot

P67871, Q3TTJ7

UniProtKB/TrEMBL

N0E4C0

Related

ENSMUSP00000025246.7, ENSMUST00000025246.13

Conserved Domains (1) summary

smart01085
Location:8 → 191

CK_II_beta; Casein kinase II regulatory subunit