Arpc1b actin related protein 2/3 complex, subunit 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arpc1bprovided by MGI
Official Full Name: actin related protein 2/3 complex, subunit 1Bprovided by MGI
Primary source: MGI:MGI:1343142
See related: Ensembl:ENSMUSG00000029622 AllianceGenome:MGI:1343142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L72; 41kDa; SOP2Hs; p41-ARC
Summary: Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Arp2/3 protein complex and tubulobulbar complex. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in colon adult (RPKM 219.0), ovary adult (RPKM 201.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 85.03 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (145051066..145064996)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (145114256..145128186)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Actin related protein 2/3 complex subunit 1 up-regulation in the hypothalamus prevents high-fat diet induced obesity.
Title: Actin related protein 2/3 complex subunit 1 up-regulation in the hypothalamus prevents high-fat diet induced obesity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124253 (e-PCR)
- UniSTS:161075

AW208418 (e-PCR)
- UniSTS:165440

RH125761 (e-PCR)
- UniSTS:162513

Arpc1b (e-PCR), detects polymorphism
- UniSTS:499170

RH125805 (e-PCR)
- UniSTS:162551

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISO Inferred from Sequence Orthology more info
part_of Arp2/3 protein complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tubulobulbar complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 1B

Names: arp2/3 complex 41 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023142.2 → NP_075631.2 actin-related protein 2/3 complex subunit 1B

See identical proteins and their annotated locations for NP_075631.2

Status: VALIDATED

Source sequence(s)

AK153510, AK159371, BF660612

Consensus CDS

CCDS19856.1

UniProtKB/Swiss-Prot

Q9CRC4, Q9WV32

UniProtKB/TrEMBL

Q3TCE7, Q3U094

Related

ENSMUSP00000082822.7, ENSMUST00000085679.13

Conserved Domains (2) summary

sd00039
Location:11 → 50

7WD40; WD40 repeat [structural motif]

cl29593
Location:45 → 264

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...