Dcp2 decapping mRNA 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcp2provided by MGI
Official Full Name: decapping mRNA 2provided by MGI
Primary source: MGI:MGI:1917890
See related: Ensembl:ENSMUSG00000024472 AllianceGenome:MGI:1917890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410015D23Rik; 5730537H01Rik
Summary: Predicted to enable 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; 5'-3' RNA exonuclease activity; and telomerase RNA binding activity. Involved in mRNA catabolic process. Predicted to be located in cell junction; cytoplasmic ribonucleoprotein granule; and nucleoplasm. Predicted to be part of RISC complex. Predicted to be active in P-body. Is expressed in several structures, including eye; genitourinary system; liver; lung; and spleen. Orthologous to human DCP2 (decapping mRNA 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.4), cerebellum adult (RPKM 6.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 23.74 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (44513567..44558036)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (44380500..44424969)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia.
Title: Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia.
Global deletion of the RNA decapping enzyme Dcp2 postnatally in male mice results in infertility.
Title: Global deletion of the RNA decapping enzyme Dcp2 postnatally in male mice results in infertility.
results suggest miR-141-3p/200a-3p may be involved in post-transcriptional repression of Dcp2 expression during renal development
Title: MicroRNA-141-3p/200a-3p target and may be involved in post-transcriptional repression of RNA decapping enzyme Dcp2 during renal development.
ERK-phosphorylated Dcp1a enhances its interaction with the decapping enzyme Dcp2 during early differentiation of 3T3-L1 cells.
Title: Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.
Recruitment of DCP1A and DCP2 increases the mRNA degradation capacity of the maturing oocyte so that by the 2-cell stage, most of the maternal mRNA is degraded.
Title: Losing mom's message: requirement for DCP1A and DCP2 in the degradation of maternal transcripts during oocyte maturation.
The results showed that DCP1A and DCP2 are critical in the transition from mRNA stability to instability during meiotic maturation and that mRNA degradation must be successful to execute the oocyte-to-zygote transition.
Title: Maternally recruited DCP1A and DCP2 contribute to messenger RNA degradation during oocyte maturation and genome activation in mouse.
In this study the increase in Irf-7 mRNA within the background of reduced Dcp2 levels was attributed to a stabilization of the Irf-7 mRNA, suggesting that Dcp2 normally modulates Irf-7 mRNA stability.
Title: Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7.
Like Dcp2, Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis.
Title: Multiple mRNA decapping enzymes in mammalian cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (2)
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:532335

Dcp2 (e-PCR), detects polymorphism
- UniSTS:532335

NoName (e-PCR)
- UniSTS:237791

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISO Inferred from Sequence Orthology more info
enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 5'-3' RNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 5'-3' RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables telomerase RNA binding	IEA Inferred from Electronic Annotation more info
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IEA Inferred from Electronic Annotation more info
involved_in histone mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in histone mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of telomerase RNA localization to Cajal body	IEA Inferred from Electronic Annotation more info
involved_in regulation of telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	ISO Inferred from Sequence Orthology more info
part_of RISC complex	ISO Inferred from Sequence Orthology more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: m7GpppN-mRNA hydrolase

Names: DCP2 decapping enzyme homolog; mRNA-decapping enzyme 2

NP_081766.1

EC 3.6.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027490.1 → NP_081766.1 m7GpppN-mRNA hydrolase

See identical proteins and their annotated locations for NP_081766.1

Status: VALIDATED

Source sequence(s)

AC147551, AK153105, AK153310

Consensus CDS

CCDS50275.1

UniProtKB/Swiss-Prot

Q3TLD9, Q9CYC6

UniProtKB/TrEMBL

Q3U671

Related

ENSMUSP00000025350.9, ENSMUST00000025350.10

Conserved Domains (2) summary

cd03672
Location:97 → 246

Dcp2p; mRNA decapping enzyme 2 (Dcp2p), the catalytic subunit, and Dcp1p are the two components of the decapping enzyme complex. Decapping is a key step in both general and nonsense-mediated 5'->3' mRNA-decay pathways. Dcp2p contains an all-alpha helical ...

pfam05026
Location:12 → 94

DCP2; Dcp2, box A domain