Cox7a1 cytochrome c oxidase subunit 7A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cox7a1provided by MGI
Official Full Name: cytochrome c oxidase subunit 7A1provided by MGI
Primary source: MGI:MGI:1316714
See related: Ensembl:ENSMUSG00000074218 AllianceGenome:MGI:1316714
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: COX7A; COX7AH; COX7AM
Summary: Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrion. Is expressed in several structures, including aorta; brown fat; heart; lung; and metanephros. Used to study dilated cardiomyopathy. Orthologous to human COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 444.7), large intestine adult (RPKM 31.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 17.31 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29883596..29885455)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30184171..30186030)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We conclude that brown adipose tissue function in mice does not require the presence of Cox7a1
Title: The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice.
We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle
Title: Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.
Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 under hypoxia; hypoxic induction of isoform Cox4i2 is HIF1a-independent.
Title: Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
Deletion of the Cox7a1 isoform results in reduced muscle bioenergetics and hindlimb capillarity
Title: Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation.
The authors show that homozygous and heterozygous Cox7a1 knockout mice, although viable, have reduced Cox activity and develop a dilated cardiomyopathy at 6 weeks of age.
Title: Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy.
A significasnt decrease in COX7AH polypeptide was observed in the myocardium of infected mice at 110 dpi, the repression being amplified with chronic disease development (330 dpi).
Title: Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cox7a1 (e-PCR), detects polymorphism
- UniSTS:141384

Cox7a1 (e-PCR), detects polymorphism
- UniSTS:499082

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to cytochrome-c oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respirasome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respirasome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of oxidative phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
located_in mitochondrion	HDA more info	PubMed
part_of respiratory chain complex	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex IV	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cytochrome c oxidase subunit 7A1, mitochondrial

Names: cytochrome c oxidase subunit VIIa 1; cytochrome c oxidase subunit VIIa-H; cytochrome c oxidase subunit VIIa-M; cytochrome c oxidase subunit VIIa-heart; cytochrome c oxidase subunit VIIa-muscle

NP_001399200.1

EC 7.1.1.9

NP_034074.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412271.1 → NP_001399200.1 cytochrome c oxidase subunit 7A1, mitochondrial isoform 1

Status: VALIDATED

Source sequence(s)

AC164703

UniProtKB/TrEMBL

A0A140LIU4

Related

ENSMUSP00000146960.2, ENSMUST00000208441.2
NM_009944.3 → NP_034074.1 cytochrome c oxidase subunit 7A1, mitochondrial isoform 2 precursor

See identical proteins and their annotated locations for NP_034074.1

Status: VALIDATED

Source sequence(s)

AK079950, BC060974

Consensus CDS

CCDS21081.1

UniProtKB/Swiss-Prot

P56392

UniProtKB/TrEMBL

Q792A4

Related

ENSMUSP00000096193.3, ENSMUST00000098594.4

Conserved Domains (1) summary

cd00928
Location:22 → 76

Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...