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    Dok5 docking protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 76829, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dok5provided by MGI
    Official Full Name
    docking protein 5provided by MGI
    Primary source
    MGI:MGI:1924079
    See related
    Ensembl:ENSMUSG00000027560 AllianceGenome:MGI:1924079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700055C10Rik
    Summary
    Acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway; neuron differentiation; and positive regulation of MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and immune system. Orthologous to human DOK5 (docking protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 19.0), CNS E14 (RPKM 9.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dok5 in Genome Data Viewer
    Location:
    2 H3; 2 92.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (170573722..170721695)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170731807..170879775)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06537 Neighboring gene STARR-seq mESC enhancer starr_06538 Neighboring gene predicted gene, 40003 Neighboring gene predicted gene, 34981 Neighboring gene predicted gene, 35033 Neighboring gene VISTA enhancer mm1402 Neighboring gene STARR-seq mESC enhancer starr_06541 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06543 Neighboring gene STARR-seq mESC enhancer starr_06544 Neighboring gene predicted gene, 46779

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/β-catenin signaling. Xu L, et al. J Musculoskelet Neuronal Interact, 2022 Mar 1. PMID 35234166, Free PMC Article
    2. MicroRNA-141-3p inhibits retinal neovascularization and retinal ganglion cell apoptosis in glaucoma mice through the inactivation of Docking protein 5-dependent mitogen-activated protein kinase signaling pathway. Zhang LQ, et al. J Cell Physiol, 2019 Jun. PMID 30515784
    3. Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway. Wen J, et al. J Mol Cell Cardiol, 2009 Dec. PMID 19800350
    4. The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis. Yasuoka H, et al. PLoS One, 2014. PMID 24551065, Free PMC Article
    5. Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Pan Y, et al. Neurosci Lett, 2013 Oct 11. PMID 23954828

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/beta-catenin signaling.
      Title: Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/β-catenin signaling.
    2. The study suggests that miR-141-3p inhibits retinal neovascularization in glaucoma mice by impeding the activation of the DOK5-mediated MAPK signaling pathway.
      Title: MicroRNA-141-3p inhibits retinal neovascularization and retinal ganglion cell apoptosis in glaucoma mice through the inactivation of Docking protein 5-dependent mitogen-activated protein kinase signaling pathway.
    3. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
      Title: The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.
    4. Dok5 is necessary for NT-3 signaling to block TrkC-induced apoptosis
      Title: Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.
    5. FOXO3a, the PI3K/PKB downstream substrate, acts as a transcriptional repressor to inhibit the expression of Dok-5.
      Title: Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 5
    Names
    downstream of tyrosine kinase 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163686.1 → NP_001157158.1  docking protein 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK044148, BY248468, BY657780, CJ064232
      UniProtKB/TrEMBL
      Q6NXY7
      Conserved Domains (3) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
      pfam00169
      Location:8 → 111
      PH; PH domain

    2. NM_029761.4 → NP_084037.3  docking protein 5 isoform 1

      See identical proteins and their annotated locations for NP_084037.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK044148, BY248468, BY657780, CJ064232
      Consensus CDS
      CCDS17125.1
      UniProtKB/Swiss-Prot
      Q8BRI3, Q91ZM9, Q9CSM6
      UniProtKB/TrEMBL
      Q6NXY7
      Related
      ENSMUSP00000029075.5, ENSMUST00000029075.5
      Conserved Domains (3) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
      pfam00169
      Location:8 → 111
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      170573722..170721695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162678.1 → XP_036018571.1  docking protein 5 isoform X1

      Conserved Domains (1) summary
      cl17171
      Location:53 → 129
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZM9.1 GenPept UniProtKB/Swiss-Prot:Q91ZM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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