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    PRXL2C peroxiredoxin like 2C [ Homo sapiens (human) ]

    Gene ID: 195827, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PRXL2Cprovided by HGNC
    Official Full Name
    peroxiredoxin like 2Cprovided by HGNC
    Primary source
    HGNC:HGNC:16881
    See related
    Ensembl:ENSG00000158122 AllianceGenome:HGNC:16881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAED1; C9orf21
    Summary
    Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.8), gall bladder (RPKM 7.6) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See PRXL2C in Genome Data Viewer
    Location:
    9q22.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (96639577..96655317, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (108811352..108827123, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99401859..99417599, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20085 Neighboring gene hyaluronan binding protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99256389-99257179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99257792-99258292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99273815-99274314 Neighboring gene cell division cycle 14B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:99284685-99285884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20087 Neighboring gene MPRA-validated peak7299 silencer Neighboring gene uncharacterized LOC105376163 Neighboring gene MPRA-validated peak7301 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:99381276-99381776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99428933-99429433 Neighboring gene Sharpr-MPRA regulatory region 12242 Neighboring gene makorin ring finger protein 10, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20091 Neighboring gene zinc finger protein 510

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. AAED1 modulates proliferation and glycolysis in gastric cancer. Zhang B, et al. Oncol Rep, 2018 Aug. PMID 29901208
    2. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. Gilligan P, et al. Gene, 2002 Jul 10. PMID 12234665
    3. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. Castellano S, et al. EMBO Rep, 2004 Jan. PMID 14710190, Free PMC Article
    4. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
    5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxiredoxin-like 2C
    Names
    AhpC/TSA antioxidant enzyme domain containing 1
    UPF0308 protein C9orf21
    ahpC/TSA antioxidant enzyme domain-containing protein 1
    thioredoxin-like protein AAED1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153698.2 → NP_714542.1  peroxiredoxin-like 2C

      See identical proteins and their annotated locations for NP_714542.1

      Status: VALIDATED

      Source sequence(s)
      AL353578, BF445089, BM843088, BU631382
      Consensus CDS
      CCDS35073.1
      UniProtKB/Swiss-Prot
      B2RMW4, Q5JU02, Q7RTV5
      Related
      ENSP00000364382.3, ENST00000375234.8
      Conserved Domains (1) summary
      cd02970
      Location:34 → 195
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      96639577..96655317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422905.1 → XP_047278861.1  peroxiredoxin-like 2C isoform X3

      UniProtKB/TrEMBL
      H0Y7F1
      Related
      ENSP00000412378.1, ENST00000411939.5

    2. XM_005251784.5 → XP_005251841.1  peroxiredoxin-like 2C isoform X2

      See identical proteins and their annotated locations for XP_005251841.1

      UniProtKB/TrEMBL
      B7ZKK1, H0Y5J5
      Related
      ENSP00000398933.1, ENST00000446045.1
      Conserved Domains (1) summary
      cd02970
      Location:11 → 141
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    3. XM_005251783.4 → XP_005251840.1  peroxiredoxin-like 2C isoform X1

      See identical proteins and their annotated locations for XP_005251840.1

      Conserved Domains (1) summary
      cd02970
      Location:34 → 168
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      108811352..108827123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362236.1 → XP_054218211.1  peroxiredoxin-like 2C isoform X3

      UniProtKB/TrEMBL
      H0Y7F1

    2. XM_054362235.1 → XP_054218210.1  peroxiredoxin-like 2C isoform X2

      UniProtKB/TrEMBL
      B7ZKK1, H0Y5J5

    3. XM_054362234.1 → XP_054218209.1  peroxiredoxin-like 2C isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7RTV5.1 GenPept UniProtKB/Swiss-Prot:Q7RTV5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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